Regional changes in the rate of turnover of acetylcholine in rat brain following diazepam or muscimol

G. Zsilla, D. L. Cheney, E. Costa

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Muscimol (8.8 μmol/kg i.v.) and diazepam (7.04 μmol/kg i.p.) decreased the rate of turnover of acetylcholine in midbrain and cortex of rat brain but failed to change acetylcholine turnover in striatum and hippocampus. The similarity in the profile of the action of diazepam and muscimol on acetylcholine turnover in various brain structures adds support to the view thet GABA participates in mediating the actions of diazepam. Since the striatum contains an abundance of GABA neurones and intrinsic cholinergic neurones, it is inferred that the metabolism of acetylcholine, and presumably the activity of striatal cholinergic neurones are not regulated by the activation of GABA receptors. Similar considerations apply to the cholinergic pathway projecting from the septum to the hippocampus.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume294
Issue number3
DOIs
Publication statusPublished - Sep 1976

Fingerprint

Muscimol
Diazepam
Acetylcholine
Cholinergic Neurons
Brain
Hippocampus
Corpus Striatum
GABAergic Neurons
GABA Receptors
Mesencephalon
gamma-Aminobutyric Acid
Cholinergic Agents

Keywords

  • Acetylcholine turnover
  • Diazepam
  • GABA receptors
  • Muscimol

ASJC Scopus subject areas

  • Pharmacology

Cite this

Regional changes in the rate of turnover of acetylcholine in rat brain following diazepam or muscimol. / Zsilla, G.; Cheney, D. L.; Costa, E.

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 294, No. 3, 09.1976, p. 251-255.

Research output: Contribution to journalArticle

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