Regional blood-to-tissue transport in RT-9 brain tumors

P. Molnár, R. G. Blasberg, M. Horowitz, B. Smith, J. Fenstermacher

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Abstract

Regional blood-to-tissue transport, expressed as a unidirectional transfer rate constant (K), was measured in experimental RT-9 brain tumors using 14C-alpha-aminoisobutyric acid (AIB) and quantitative autoradiographic techniques. The magnitude of K depends on the permeability, surface area, and blood flow of the tissue capillaries. The transfer rate constant was variable within tumor tissue (range 0.001 to 0.178 ml/gm/min) and depended on tumor size, location (intraparenchymal, meningeal, or choroid plexus associated), and to a lesser extent on necrosis and cyst formation. Brain adjacent to tumor had higher K values, particularly around larger tumors (0.004 to 0.014 ml/gm/min), than corresponding brain regions in the contralateral hemisphere (0.001 to 0.002 ml/gm/min). Estimates of the fractional extraction of AIB by intraparenchymal tumors were between 0.008 and 0.4 ml/gm/min. Values of fractional extraction in this range indicate that tumor capillaries are not freely permeable to this solute. The values of K measured with AIB in this study, for the most part, approximate the permeability-surface area product of tumor and brain capillaries. The experimental data suggest that the permeability-surface area characteristics of the microvasculature in small RT-9 tumors are similar to those of the host tissue, whereas the microvasculature of larger RT-9 tumors is influenced more by intrinsic tumor factors

Original languageEnglish
Pages (from-to)874-884
Number of pages11
JournalJournal of Neurosurgery
Volume58
Issue number6
Publication statusPublished - 1983

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Brain Neoplasms
Neoplasms
Aminoisobutyric Acids
Permeability
Microvessels
Intrinsic Factor
Choroid Plexus
Brain
Cysts
Necrosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Molnár, P., Blasberg, R. G., Horowitz, M., Smith, B., & Fenstermacher, J. (1983). Regional blood-to-tissue transport in RT-9 brain tumors. Journal of Neurosurgery, 58(6), 874-884.

Regional blood-to-tissue transport in RT-9 brain tumors. / Molnár, P.; Blasberg, R. G.; Horowitz, M.; Smith, B.; Fenstermacher, J.

In: Journal of Neurosurgery, Vol. 58, No. 6, 1983, p. 874-884.

Research output: Contribution to journalArticle

Molnár, P, Blasberg, RG, Horowitz, M, Smith, B & Fenstermacher, J 1983, 'Regional blood-to-tissue transport in RT-9 brain tumors', Journal of Neurosurgery, vol. 58, no. 6, pp. 874-884.
Molnár P, Blasberg RG, Horowitz M, Smith B, Fenstermacher J. Regional blood-to-tissue transport in RT-9 brain tumors. Journal of Neurosurgery. 1983;58(6):874-884.
Molnár, P. ; Blasberg, R. G. ; Horowitz, M. ; Smith, B. ; Fenstermacher, J. / Regional blood-to-tissue transport in RT-9 brain tumors. In: Journal of Neurosurgery. 1983 ; Vol. 58, No. 6. pp. 874-884.
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