Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors

Dennis Groothuis, Ronald G. Blasberg, Peter Molnar, Darell Bigner, Joseph D. Fenstermacher

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Regional blood flow (F) was measured in avian sarcoma virus (ASV)-induced brain tumors in rats. Blood flow was variable in individual as well as different tumors; tumor F did not correlate with histologic classification, tumor size, central versus peripheral tumor regions, intraparenchymal location, cell density, or specific cytologic characteristics. Low values of F did correlate with tumor necrosis and hydrocephalus; high values of F correlated with tumorous invasion or association with choroid plexus. Mean tumor F was not significantly different from that of the same anatomic, tumor-free brain region of the contralateral hemisphere, but F in brain tissue adjacent to the tumor was depressed significantly. Depression of F was observed in tumor-free cortex and corpus callosum, especially in the hemisphere ipsilateral to the main tumor mass and in those animals with hydrocephalus.

Original languageEnglish
Pages (from-to)686-696
Number of pages11
Issue number6
Publication statusPublished - Jun 1983


ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Groothuis, D., Blasberg, R. G., Molnar, P., Bigner, D., & Fenstermacher, J. D. (1983). Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors. Neurology, 33(6), 686-696.