Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors

Dennis Groothuis, Ronald G. Blasberg, P. Molnár, Darell Bigner, Joseph D. Fenstermacher

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Regional blood flow (F) was measured in avian sarcoma virus (ASV)-induced brain tumors in rats. Blood flow was variable in individual as well as different tumors; tumor F did not correlate with histologic classification, tumor size, central versus peripheral tumor regions, intraparenchymal location, cell density, or specific cytologic characteristics. Low values of F did correlate with tumor necrosis and hydrocephalus; high values of F correlated with tumorous invasion or association with choroid plexus. Mean tumor F was not significantly different from that of the same anatomic, tumor-free brain region of the contralateral hemisphere, but F in brain tissue adjacent to the tumor was depressed significantly. Depression of F was observed in tumor-free cortex and corpus callosum, especially in the hemisphere ipsilateral to the main tumor mass and in those animals with hydrocephalus.

Original languageEnglish
Pages (from-to)686-696
Number of pages11
JournalNeurology
Volume33
Issue number6
Publication statusPublished - 1983

Fingerprint

Avian Sarcoma Viruses
Regional Blood Flow
Brain Neoplasms
Neoplasms
Hydrocephalus
Virus
Blood
Hemisphere
Brain Tumor
Choroid Plexus
Corpus Callosum
Necrosis
Cell Count

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Groothuis, D., Blasberg, R. G., Molnár, P., Bigner, D., & Fenstermacher, J. D. (1983). Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors. Neurology, 33(6), 686-696.

Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors. / Groothuis, Dennis; Blasberg, Ronald G.; Molnár, P.; Bigner, Darell; Fenstermacher, Joseph D.

In: Neurology, Vol. 33, No. 6, 1983, p. 686-696.

Research output: Contribution to journalArticle

Groothuis, D, Blasberg, RG, Molnár, P, Bigner, D & Fenstermacher, JD 1983, 'Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors', Neurology, vol. 33, no. 6, pp. 686-696.
Groothuis D, Blasberg RG, Molnár P, Bigner D, Fenstermacher JD. Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors. Neurology. 1983;33(6):686-696.
Groothuis, Dennis ; Blasberg, Ronald G. ; Molnár, P. ; Bigner, Darell ; Fenstermacher, Joseph D. / Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors. In: Neurology. 1983 ; Vol. 33, No. 6. pp. 686-696.
@article{012b07b4468f4efd9449d0d37a41194f,
title = "Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors",
abstract = "Regional blood flow (F) was measured in avian sarcoma virus (ASV)-induced brain tumors in rats. Blood flow was variable in individual as well as different tumors; tumor F did not correlate with histologic classification, tumor size, central versus peripheral tumor regions, intraparenchymal location, cell density, or specific cytologic characteristics. Low values of F did correlate with tumor necrosis and hydrocephalus; high values of F correlated with tumorous invasion or association with choroid plexus. Mean tumor F was not significantly different from that of the same anatomic, tumor-free brain region of the contralateral hemisphere, but F in brain tissue adjacent to the tumor was depressed significantly. Depression of F was observed in tumor-free cortex and corpus callosum, especially in the hemisphere ipsilateral to the main tumor mass and in those animals with hydrocephalus.",
author = "Dennis Groothuis and Blasberg, {Ronald G.} and P. Moln{\'a}r and Darell Bigner and Fenstermacher, {Joseph D.}",
year = "1983",
language = "English",
volume = "33",
pages = "686--696",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors

AU - Groothuis, Dennis

AU - Blasberg, Ronald G.

AU - Molnár, P.

AU - Bigner, Darell

AU - Fenstermacher, Joseph D.

PY - 1983

Y1 - 1983

N2 - Regional blood flow (F) was measured in avian sarcoma virus (ASV)-induced brain tumors in rats. Blood flow was variable in individual as well as different tumors; tumor F did not correlate with histologic classification, tumor size, central versus peripheral tumor regions, intraparenchymal location, cell density, or specific cytologic characteristics. Low values of F did correlate with tumor necrosis and hydrocephalus; high values of F correlated with tumorous invasion or association with choroid plexus. Mean tumor F was not significantly different from that of the same anatomic, tumor-free brain region of the contralateral hemisphere, but F in brain tissue adjacent to the tumor was depressed significantly. Depression of F was observed in tumor-free cortex and corpus callosum, especially in the hemisphere ipsilateral to the main tumor mass and in those animals with hydrocephalus.

AB - Regional blood flow (F) was measured in avian sarcoma virus (ASV)-induced brain tumors in rats. Blood flow was variable in individual as well as different tumors; tumor F did not correlate with histologic classification, tumor size, central versus peripheral tumor regions, intraparenchymal location, cell density, or specific cytologic characteristics. Low values of F did correlate with tumor necrosis and hydrocephalus; high values of F correlated with tumorous invasion or association with choroid plexus. Mean tumor F was not significantly different from that of the same anatomic, tumor-free brain region of the contralateral hemisphere, but F in brain tissue adjacent to the tumor was depressed significantly. Depression of F was observed in tumor-free cortex and corpus callosum, especially in the hemisphere ipsilateral to the main tumor mass and in those animals with hydrocephalus.

UR - http://www.scopus.com/inward/record.url?scp=0020577787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020577787&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 686

EP - 696

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 6

ER -