Regio entorhinalis in Schizophrenia: More Evidence for Migrational Disturbances and Suggestions for a New Biological Hypothesis

S. Kovalenko, A. Bergmann, T. Schneider-Axmann, I. Ovary, K. Majtenyi, L. Havas, W. G. Honer, B. Bogerts, P. Falkai

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Abstract

Recently we were able to replicate the original finding of migrational disturbances in the entorhinol cortex (ERC) of schizophrenic patients by measuring the distance of pre-alpha cell clusters to the pial surface. In order to replicate this finding, we performed a detailed analysis of the pre-alpha cell clusters in the ERC in post mortem brains of 22 schizophrenic patients and 15 control subjects. Cluster position relative to gray/white matter boundary were measured and normalized by the widths of the gray matter. In the ERC the pre-alpha cell clusters were situated significantly closer to the gray/white matter junction compared to normal controls (around 30%, F = 9.52, p = 0.004). No specific effects of sex, age or region of investigation were found. In summary, this is another quantitative replication of pre-alpha cell cluster migrational disturbances in schizophrenia, which are possibly linked to neurobiological abnormalities, e.g. myeloarchitectonic changes. This supports the notion that developmental abnormalities are a core feature of schizophrenia and that the search for candidate genes has to include this aspect, too. However, it is very probable that vulnerability-associated changes -as outlined here - have to be distinguished from disease-related changes.

Original languageEnglish
Pages (from-to)S158-S161
JournalPharmacopsychiatry
Volume36
Issue numberSUPPL. 3
Publication statusPublished - Nov 1 2003

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Keywords

  • ERC
  • Neurodevelopment
  • Neuronal migration
  • Post mortem
  • Pre-alpha cell clusters
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Kovalenko, S., Bergmann, A., Schneider-Axmann, T., Ovary, I., Majtenyi, K., Havas, L., Honer, W. G., Bogerts, B., & Falkai, P. (2003). Regio entorhinalis in Schizophrenia: More Evidence for Migrational Disturbances and Suggestions for a New Biological Hypothesis. Pharmacopsychiatry, 36(SUPPL. 3), S158-S161.