A regio- and stereoselective approach to fluorinated β- aminocyclohexene or cyclohexane esters has been developed, starting from a bicyclic β-lactam (1). The procedure involves six or seven steps, based on regio- and stereoselective iodolactonization, lactone opening and hydroxy-fluorine exchange. The method has been extended to the synthesis of fluorinated amino ester enantiomers.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry