Regio- and diastereoselective fluorination of alicyclic β-amino acids

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25 Citations (Scopus)


A regio- and stereoselective approach to fluorinated β- aminocyclohexene or cyclohexane esters has been developed, starting from a bicyclic β-lactam (1). The procedure involves six or seven steps, based on regio- and stereoselective iodolactonization, lactone opening and hydroxy-fluorine exchange. The method has been extended to the synthesis of fluorinated amino ester enantiomers.

Original languageEnglish
Pages (from-to)6528-6534
Number of pages7
JournalOrganic and Biomolecular Chemistry
Issue number19
Publication statusPublished - Oct 7 2011

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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