Refrakter sprue mint az enteropathia típusú T-sejtes lymphoma prekurzor laesiója - Klinikopatológiai esetismertetés

Translated title of the contribution: Refractory sprue - Precursor lesion of enteropathy type T-cell lymphoma

E. Bagdi, József Kiss, Zita Borbényi, Klára Piukovics, L. Krenács

Research output: Contribution to journalArticle

Abstract

Introduction: Refractory sprue is characterised by distinctive morphologic alterations and the emergence of clonal intraepithelial lymphocytes. Aim: In this case report the authors emphasize the importance of histopathology in the diagnosis of refractory sprue. Methods: The sequential biopsies from this patient have been investigated with routine histology, immunohistochemistry and molecular genetics for T-cell clonality analysis. Results: The severely cachectic patient presenting with malabsorbtion syndrome has been diagnosed with celiac disease through a duodenal biopsy, and the CD8 negativity of the intraepithelial lymphocytes suggested the possible diagnosis of refractory sprue. Azathioprine and glucocorticoid therapy was administered due to the failed jejunal feeding and gluten-free diet, resulting in clinically complete, morphologically partial remission. Intestinal T-cell lymphoma developed in the ileocecal region within two years after the first clinical presentation. Discussion: Refractery sprue and the enteropathy-type T-cell lymphoma constitute a disease spectrum. The reported case shows how a simple method can provide crucial information in the diagnosis of refractory sprue.

Original languageHungarian
Pages (from-to)995-998
Number of pages4
JournalOrvosi Hetilap
Volume149
Issue number21
DOIs
Publication statusPublished - May 25 2008

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T-Cell Lymphoma
Celiac Disease
Lymphocytes
Biopsy
Gluten-Free Diet
Azathioprine
Glucocorticoids
Molecular Biology
Histology
Immunohistochemistry
T-Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Refrakter sprue mint az enteropathia típusú T-sejtes lymphoma prekurzor laesiója - Klinikopatológiai esetismertetés. / Bagdi, E.; Kiss, József; Borbényi, Zita; Piukovics, Klára; Krenács, L.

In: Orvosi Hetilap, Vol. 149, No. 21, 25.05.2008, p. 995-998.

Research output: Contribution to journalArticle

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AU - Piukovics, Klára

AU - Krenács, L.

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AB - Introduction: Refractory sprue is characterised by distinctive morphologic alterations and the emergence of clonal intraepithelial lymphocytes. Aim: In this case report the authors emphasize the importance of histopathology in the diagnosis of refractory sprue. Methods: The sequential biopsies from this patient have been investigated with routine histology, immunohistochemistry and molecular genetics for T-cell clonality analysis. Results: The severely cachectic patient presenting with malabsorbtion syndrome has been diagnosed with celiac disease through a duodenal biopsy, and the CD8 negativity of the intraepithelial lymphocytes suggested the possible diagnosis of refractory sprue. Azathioprine and glucocorticoid therapy was administered due to the failed jejunal feeding and gluten-free diet, resulting in clinically complete, morphologically partial remission. Intestinal T-cell lymphoma developed in the ileocecal region within two years after the first clinical presentation. Discussion: Refractery sprue and the enteropathy-type T-cell lymphoma constitute a disease spectrum. The reported case shows how a simple method can provide crucial information in the diagnosis of refractory sprue.

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