Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

The objective in the Hungarian randomised double-blind controlled trial was to study the preventive effect of periconceptional multivitamin supplementation on neural tube-defects and other congenital abnormalities. There were 2,471 and 2,391 informative offspring (prenatally diagnosed and terminated malformed fetuses, stillborn fetuses, and liveborn infants) in the multivitamin and placebo-like trace element groups, respectively. A single tablet either of a multivitamin containing 0.8 mg of folic acid or trace element supplement was given daily for at least one month before conception and at least until the date of the second missed menstrual period. The total rate of major congenital abnormalities was 20.6/1,000 in the multivitamin and 40.6/1,000 in the trace element group. After the exclusion of six cases of neural-tube defects in the trace element group the difference was very highly significant [P = 0.0003; relative risk of 0.54 (95% CI 0.39, 0.76)]. Multivitamin supplementation appeared to result in a significant reduction in the rate of urinary tract abnormalities, mainly obstructive defects, and in the rate of sporadic cardiovascular malformations, mainly ventricular septal defects. This report is regarded as a hypothesis-generating study encouraging others to see if the result can be repeated.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume62
Issue number2
DOIs
Publication statusPublished - Mar 15 1996

Fingerprint

Trace Elements
Urinary Tract
Neural Tube Defects
Fetus
Ventricular Heart Septal Defects
Folic Acid
Tablets
Placebos

Keywords

  • congenital cardiovascular malformations
  • neural-tube defects
  • periconceptional multivitamin supplementation
  • urinary tract defects

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. / Czeizel, E.

In: American Journal of Medical Genetics, Vol. 62, No. 2, 15.03.1996, p. 179-183.

Research output: Contribution to journalArticle

@article{0ba2ad35c8224e8ebfb01f42937563a9,
title = "Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation",
abstract = "The objective in the Hungarian randomised double-blind controlled trial was to study the preventive effect of periconceptional multivitamin supplementation on neural tube-defects and other congenital abnormalities. There were 2,471 and 2,391 informative offspring (prenatally diagnosed and terminated malformed fetuses, stillborn fetuses, and liveborn infants) in the multivitamin and placebo-like trace element groups, respectively. A single tablet either of a multivitamin containing 0.8 mg of folic acid or trace element supplement was given daily for at least one month before conception and at least until the date of the second missed menstrual period. The total rate of major congenital abnormalities was 20.6/1,000 in the multivitamin and 40.6/1,000 in the trace element group. After the exclusion of six cases of neural-tube defects in the trace element group the difference was very highly significant [P = 0.0003; relative risk of 0.54 (95{\%} CI 0.39, 0.76)]. Multivitamin supplementation appeared to result in a significant reduction in the rate of urinary tract abnormalities, mainly obstructive defects, and in the rate of sporadic cardiovascular malformations, mainly ventricular septal defects. This report is regarded as a hypothesis-generating study encouraging others to see if the result can be repeated.",
keywords = "congenital cardiovascular malformations, neural-tube defects, periconceptional multivitamin supplementation, urinary tract defects",
author = "E. Czeizel",
year = "1996",
month = "3",
day = "15",
doi = "10.1002/(SICI)1096-8628(19960315)62:2<179::AID-AJMG12>3.0.CO;2-L",
language = "English",
volume = "62",
pages = "179--183",
journal = "American Journal of Medical Genetics, Part A",
issn = "1552-4825",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation

AU - Czeizel, E.

PY - 1996/3/15

Y1 - 1996/3/15

N2 - The objective in the Hungarian randomised double-blind controlled trial was to study the preventive effect of periconceptional multivitamin supplementation on neural tube-defects and other congenital abnormalities. There were 2,471 and 2,391 informative offspring (prenatally diagnosed and terminated malformed fetuses, stillborn fetuses, and liveborn infants) in the multivitamin and placebo-like trace element groups, respectively. A single tablet either of a multivitamin containing 0.8 mg of folic acid or trace element supplement was given daily for at least one month before conception and at least until the date of the second missed menstrual period. The total rate of major congenital abnormalities was 20.6/1,000 in the multivitamin and 40.6/1,000 in the trace element group. After the exclusion of six cases of neural-tube defects in the trace element group the difference was very highly significant [P = 0.0003; relative risk of 0.54 (95% CI 0.39, 0.76)]. Multivitamin supplementation appeared to result in a significant reduction in the rate of urinary tract abnormalities, mainly obstructive defects, and in the rate of sporadic cardiovascular malformations, mainly ventricular septal defects. This report is regarded as a hypothesis-generating study encouraging others to see if the result can be repeated.

AB - The objective in the Hungarian randomised double-blind controlled trial was to study the preventive effect of periconceptional multivitamin supplementation on neural tube-defects and other congenital abnormalities. There were 2,471 and 2,391 informative offspring (prenatally diagnosed and terminated malformed fetuses, stillborn fetuses, and liveborn infants) in the multivitamin and placebo-like trace element groups, respectively. A single tablet either of a multivitamin containing 0.8 mg of folic acid or trace element supplement was given daily for at least one month before conception and at least until the date of the second missed menstrual period. The total rate of major congenital abnormalities was 20.6/1,000 in the multivitamin and 40.6/1,000 in the trace element group. After the exclusion of six cases of neural-tube defects in the trace element group the difference was very highly significant [P = 0.0003; relative risk of 0.54 (95% CI 0.39, 0.76)]. Multivitamin supplementation appeared to result in a significant reduction in the rate of urinary tract abnormalities, mainly obstructive defects, and in the rate of sporadic cardiovascular malformations, mainly ventricular septal defects. This report is regarded as a hypothesis-generating study encouraging others to see if the result can be repeated.

KW - congenital cardiovascular malformations

KW - neural-tube defects

KW - periconceptional multivitamin supplementation

KW - urinary tract defects

UR - http://www.scopus.com/inward/record.url?scp=0029965863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029965863&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1096-8628(19960315)62:2<179::AID-AJMG12>3.0.CO;2-L

DO - 10.1002/(SICI)1096-8628(19960315)62:2<179::AID-AJMG12>3.0.CO;2-L

M3 - Article

C2 - 8882400

AN - SCOPUS:0029965863

VL - 62

SP - 179

EP - 183

JO - American Journal of Medical Genetics, Part A

JF - American Journal of Medical Genetics, Part A

SN - 1552-4825

IS - 2

ER -