Reduction of the toxicity of 'radiomimetic' alkylating agents in rats by thiol pretreatment-III. The mechanism of the protective action of thiosulphate

T. A. Connors, A. Jeney, M. Jones

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Thiosulphate affords good protection against the toxicity of HN2 but none against the toxicity of an aromatic nitrogen mustard Merophan. Cysteine, however, gave a good protection against the toxicity of both these mustards. These results can be explained on the basis of the different mechanisms by which the aliphatic and aromatic nitrogens mustard alkylate. Mixtures of thiosulphate and cysteine gave good protection against HN2 toxicity but little against Merophan, which suggests that thiosulphate may prevent cysteine from entering cells.

Original languageEnglish
Pages (from-to)1545-1550
Number of pages6
JournalBiochemical Pharmacology
Volume13
Issue number12
Publication statusPublished - Dec 1964

Fingerprint

Thiosulfates
Alkylating Agents
Sulfhydryl Compounds
Cysteine
Toxicity
Rats
Mechlorethamine
Mustard Plant

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry

Cite this

Reduction of the toxicity of 'radiomimetic' alkylating agents in rats by thiol pretreatment-III. The mechanism of the protective action of thiosulphate. / Connors, T. A.; Jeney, A.; Jones, M.

In: Biochemical Pharmacology, Vol. 13, No. 12, 12.1964, p. 1545-1550.

Research output: Contribution to journalArticle

@article{4fa76943a3b24ef68f0d1e1bb4188156,
title = "Reduction of the toxicity of 'radiomimetic' alkylating agents in rats by thiol pretreatment-III. The mechanism of the protective action of thiosulphate",
abstract = "Thiosulphate affords good protection against the toxicity of HN2 but none against the toxicity of an aromatic nitrogen mustard Merophan. Cysteine, however, gave a good protection against the toxicity of both these mustards. These results can be explained on the basis of the different mechanisms by which the aliphatic and aromatic nitrogens mustard alkylate. Mixtures of thiosulphate and cysteine gave good protection against HN2 toxicity but little against Merophan, which suggests that thiosulphate may prevent cysteine from entering cells.",
author = "Connors, {T. A.} and A. Jeney and M. Jones",
year = "1964",
month = "12",
language = "English",
volume = "13",
pages = "1545--1550",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Reduction of the toxicity of 'radiomimetic' alkylating agents in rats by thiol pretreatment-III. The mechanism of the protective action of thiosulphate

AU - Connors, T. A.

AU - Jeney, A.

AU - Jones, M.

PY - 1964/12

Y1 - 1964/12

N2 - Thiosulphate affords good protection against the toxicity of HN2 but none against the toxicity of an aromatic nitrogen mustard Merophan. Cysteine, however, gave a good protection against the toxicity of both these mustards. These results can be explained on the basis of the different mechanisms by which the aliphatic and aromatic nitrogens mustard alkylate. Mixtures of thiosulphate and cysteine gave good protection against HN2 toxicity but little against Merophan, which suggests that thiosulphate may prevent cysteine from entering cells.

AB - Thiosulphate affords good protection against the toxicity of HN2 but none against the toxicity of an aromatic nitrogen mustard Merophan. Cysteine, however, gave a good protection against the toxicity of both these mustards. These results can be explained on the basis of the different mechanisms by which the aliphatic and aromatic nitrogens mustard alkylate. Mixtures of thiosulphate and cysteine gave good protection against HN2 toxicity but little against Merophan, which suggests that thiosulphate may prevent cysteine from entering cells.

UR - http://www.scopus.com/inward/record.url?scp=1542710466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542710466&partnerID=8YFLogxK

M3 - Article

C2 - 14248383

AN - SCOPUS:1542710466

VL - 13

SP - 1545

EP - 1550

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

IS - 12

ER -