Reduction of substance P binding sites in the spinal dorsal horn after perineural capsaicin treatment in the rat

Holger Sann, G. Jancsó, Walter Rössler, Friedrich Karl Pierau

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The long-term effect of perineural capsaicin treatment on the distribution of substance P (SP) binding sites was studied in the rat spinal dorsal horn using 125I-labelled Bolton-Hunter-SP. Three months after local application of capsaicin onto the sciatic nerve quantitative evaluation of the autoradiograms revealed a significant decrease in the densiy of SP binding sites of up to 48% in regions of laminae I and II of the spinal dorsal horn somatotopically related to the capsaicin treated sciatic nerve. It is suggested that reduction in SP binding may result from transganglionic and transsynaptic degenerative changes affecting postsynaptic structures. Changes in the distribution of SP binding sites may significantly contribute to functional alterations observed after perineural treatment with capsaicin.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalNeuroscience Letters
Volume190
Issue number3
DOIs
Publication statusPublished - May 12 1995

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Capsaicin
Substance P
Binding Sites
Sciatic Nerve
Substantia Gelatinosa
Spinal Cord Dorsal Horn

Keywords

  • Autoradiography
  • Binding sites
  • Capsaicin
  • Primary afferents
  • Spinal cord
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reduction of substance P binding sites in the spinal dorsal horn after perineural capsaicin treatment in the rat. / Sann, Holger; Jancsó, G.; Rössler, Walter; Pierau, Friedrich Karl.

In: Neuroscience Letters, Vol. 190, No. 3, 12.05.1995, p. 151-154.

Research output: Contribution to journalArticle

Sann, Holger ; Jancsó, G. ; Rössler, Walter ; Pierau, Friedrich Karl. / Reduction of substance P binding sites in the spinal dorsal horn after perineural capsaicin treatment in the rat. In: Neuroscience Letters. 1995 ; Vol. 190, No. 3. pp. 151-154.
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