Reduction of glycated hemoglobin levels by long term, high dose ascorbic acid supplementation in healthy and diabetic patients

E. Szaleczky, J. Prechl, E. Ruzicska, J. Fehér, L. Braun, G. Bánhegyi, M. Csala, J. Mandi, A. Somogyi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of long term, high dose ascorbic acid supplementation on blood glucose concentration levels was investigated upon in 17 healthy and 19 diabetic patients measuring their glycated hemoglobin (HbA(1c)) levels. Ascorbic acid treatment resulted in a significant reduction in HbA(1c) (7 and 9% of initial values in control and diabetic groups, respectively). The extent of the reduction was dependent on initial glycated hemoglobin levels in both groups, therefore, the effect of ascorbic acid was more pronounced in the diabetic group. Ascorbic acid supplementation elevated the plasma levels of reduced glutathione by 81 and 108 %. in control and diabetic groups, respectively. It is suggested that the increase of serum antioxidant glutathione and the decrease of glycated hemoglobin after long term ascorbic acid supplementation are related to each other.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalMedical Science Monitor
Volume4
Issue number2
Publication statusPublished - 1998

Fingerprint

Glycosylated Hemoglobin A
Ascorbic Acid
Glutathione
Control Groups
Blood Glucose
Antioxidants
Serum

Keywords

  • Ascorbate
  • Ascorbic acid
  • Diabetes
  • Glucose
  • Glutathione
  • Glycation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{23f2f26aab6b492195bb164ce3d4e5c5,
title = "Reduction of glycated hemoglobin levels by long term, high dose ascorbic acid supplementation in healthy and diabetic patients",
abstract = "The effect of long term, high dose ascorbic acid supplementation on blood glucose concentration levels was investigated upon in 17 healthy and 19 diabetic patients measuring their glycated hemoglobin (HbA(1c)) levels. Ascorbic acid treatment resulted in a significant reduction in HbA(1c) (7 and 9{\%} of initial values in control and diabetic groups, respectively). The extent of the reduction was dependent on initial glycated hemoglobin levels in both groups, therefore, the effect of ascorbic acid was more pronounced in the diabetic group. Ascorbic acid supplementation elevated the plasma levels of reduced glutathione by 81 and 108 {\%}. in control and diabetic groups, respectively. It is suggested that the increase of serum antioxidant glutathione and the decrease of glycated hemoglobin after long term ascorbic acid supplementation are related to each other.",
keywords = "Ascorbate, Ascorbic acid, Diabetes, Glucose, Glutathione, Glycation",
author = "E. Szaleczky and J. Prechl and E. Ruzicska and J. Feh{\'e}r and L. Braun and G. B{\'a}nhegyi and M. Csala and J. Mandi and A. Somogyi",
year = "1998",
language = "English",
volume = "4",
pages = "241--244",
journal = "Medical Science Monitor",
issn = "1234-1010",
publisher = "International Scientific Literature Inc.",
number = "2",

}

TY - JOUR

T1 - Reduction of glycated hemoglobin levels by long term, high dose ascorbic acid supplementation in healthy and diabetic patients

AU - Szaleczky, E.

AU - Prechl, J.

AU - Ruzicska, E.

AU - Fehér, J.

AU - Braun, L.

AU - Bánhegyi, G.

AU - Csala, M.

AU - Mandi, J.

AU - Somogyi, A.

PY - 1998

Y1 - 1998

N2 - The effect of long term, high dose ascorbic acid supplementation on blood glucose concentration levels was investigated upon in 17 healthy and 19 diabetic patients measuring their glycated hemoglobin (HbA(1c)) levels. Ascorbic acid treatment resulted in a significant reduction in HbA(1c) (7 and 9% of initial values in control and diabetic groups, respectively). The extent of the reduction was dependent on initial glycated hemoglobin levels in both groups, therefore, the effect of ascorbic acid was more pronounced in the diabetic group. Ascorbic acid supplementation elevated the plasma levels of reduced glutathione by 81 and 108 %. in control and diabetic groups, respectively. It is suggested that the increase of serum antioxidant glutathione and the decrease of glycated hemoglobin after long term ascorbic acid supplementation are related to each other.

AB - The effect of long term, high dose ascorbic acid supplementation on blood glucose concentration levels was investigated upon in 17 healthy and 19 diabetic patients measuring their glycated hemoglobin (HbA(1c)) levels. Ascorbic acid treatment resulted in a significant reduction in HbA(1c) (7 and 9% of initial values in control and diabetic groups, respectively). The extent of the reduction was dependent on initial glycated hemoglobin levels in both groups, therefore, the effect of ascorbic acid was more pronounced in the diabetic group. Ascorbic acid supplementation elevated the plasma levels of reduced glutathione by 81 and 108 %. in control and diabetic groups, respectively. It is suggested that the increase of serum antioxidant glutathione and the decrease of glycated hemoglobin after long term ascorbic acid supplementation are related to each other.

KW - Ascorbate

KW - Ascorbic acid

KW - Diabetes

KW - Glucose

KW - Glutathione

KW - Glycation

UR - http://www.scopus.com/inward/record.url?scp=0031966626&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031966626&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 241

EP - 244

JO - Medical Science Monitor

JF - Medical Science Monitor

SN - 1234-1010

IS - 2

ER -