Reduction of coronary flow reserve in patients with increased aortic stiffness

Attila Nemes, T. Forster, M. Csanády

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aortic stiffness is thought to affect coronary blood flow, but little is known about its influence on coronary flow reserve (CFR). The objective of the present study was to investigate the relationship between aortic stiffness and CFR in matched patients with and without increased aortic stiffness. Stress transoesophageal echocardiography (TEE) as the CFR measurement and coronary angiography were performed in all cases. Increased aortic stiffness was defined if elastic modulus Ep > 680 mmHg. The following patient populations free of coronary artery disease were compared: 36 subjects with normal aortic distensibility and 19 age-, sex-, and risk factor-matched patients with increased aortic stiffness. CFR was significantly reduced in patients with increased aortic stiffness as compared with cases with normal aortic distensibility (2.64 ± 1.16 vs. 2.12 ± 0.58, p <0.01). Hyperaemic diastolic flow velocities were reduced in patients with increased aortic stiffness (129.5 ± 36.6 cm/s vs. 102.1 ± 39.8 cm/s, p <0.05). Negative correlations were found between Ep and hyperaemic diastolic coronary flow velocity (r = -0.41, p <0.01) and CFR (r = -0.21, p <0.05). CFR is reduced in patients with increased aortic stiffness and negative correlations exist between these functional parameters.

Original languageEnglish
Pages (from-to)818-822
Number of pages5
JournalCanadian Journal of Physiology and Pharmacology
Volume85
Issue number8
DOIs
Publication statusPublished - Aug 2007

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Vascular Stiffness
Sex Factors
Stress Echocardiography
Elastic Modulus
Age Factors
Transesophageal Echocardiography
Coronary Angiography
Coronary Artery Disease

Keywords

  • Aortic distensibility
  • Coronary flow reserve
  • Echocardiography

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

Reduction of coronary flow reserve in patients with increased aortic stiffness. / Nemes, Attila; Forster, T.; Csanády, M.

In: Canadian Journal of Physiology and Pharmacology, Vol. 85, No. 8, 08.2007, p. 818-822.

Research output: Contribution to journalArticle

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