Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism

Maria T. Lazaro, Jiannis Taxidis, Tristan Shuman, Iris Bachmutsky, Taruna Ikrar, Rommel Santos, G. Mark Marcello, Apoorva Mylavarapu, Swasty Chandra, Allison Foreman, Rachna Goli, Duy Tran, Nikhil Sharma, Michelle Azhdam, Hongmei Dong, Katrina Y. Choe, Olga Peñagarikano, Sotiris C. Masmanidis, Bence Rácz, Xiangmin XuDaniel H. Geschwind, Peyman Golshani

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Lazaro et al. demonstrate a decrease in synaptic inputs onto mPFC L2/3 pyramidal neurons of Cntnap2 KO mice, concurrent with reduced spines and synapses. These lead to perturbed network activity, with mPFC cells exhibiting reduced phase locking and altered preferred phases to slow LFP oscillations, which may underlie autism-related phenotypes.

Original languageEnglish
Pages (from-to)2567-2578.e6
JournalCell Reports
Volume27
Issue number9
DOIs
Publication statusPublished - May 28 2019

Keywords

  • EEG
  • biomarker
  • brain state
  • connectivity
  • delta
  • functional
  • inhibition
  • oscillation
  • phase-locking
  • theta

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Lazaro, M. T., Taxidis, J., Shuman, T., Bachmutsky, I., Ikrar, T., Santos, R., Marcello, G. M., Mylavarapu, A., Chandra, S., Foreman, A., Goli, R., Tran, D., Sharma, N., Azhdam, M., Dong, H., Choe, K. Y., Peñagarikano, O., Masmanidis, S. C., Rácz, B., ... Golshani, P. (2019). Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism. Cell Reports, 27(9), 2567-2578.e6. https://doi.org/10.1016/j.celrep.2019.05.006