Reduced neutrophil superoxide generation and plasma lipoperoxide levels in pigs fed with cod liver oil

Carlo Guarnieri, Li You‐Zhou, Elizabeth Roth, Pierluigi Biagi, Giovanni Ussia, Elisabetta Baccarini, Francesco Farruggia, Gary L. Anderson, John H. Barker, Giovanni Galletti

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Circulating neutrophils, isolated from pigs fed for 8 weeks with a diet supplemented with CLO, had an accentuated n‐3 fatty acid incorporation into the plasma membrane, as evidenced by an approximately four‐fold greater n‐3/n‐6 ratio as compared with the control diet group. Moreover, the neutrophils of the CLO fed pigs produced less superoxide when stimulated with PMA or f‐MLP, as well as showing a more prolonged latency period before O2‐generation. In the plasma of pigs fed with CLO there were higher levels of thiobarbituric reactive material and lipofuscin, while the content of GSSG was similar in both dietary groups. The results of this study indicate that dietary supplementation with CLO reduces the activation of circulating neutrophils and favours the presence in the plasma of lipoperoxides.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalCell biochemistry and function
Volume9
Issue number4
DOIs
Publication statusPublished - Oct 1991

    Fingerprint

Keywords

  • Neutrophils
  • Pigs
  • cod liver oil
  • plasma peroxide
  • polyunsaturated fatty acids
  • superoxide

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology

Cite this

Guarnieri, C., You‐Zhou, L., Roth, E., Biagi, P., Ussia, G., Baccarini, E., Farruggia, F., Anderson, G. L., Barker, J. H., & Galletti, G. (1991). Reduced neutrophil superoxide generation and plasma lipoperoxide levels in pigs fed with cod liver oil. Cell biochemistry and function, 9(4), 239-243. https://doi.org/10.1002/cbf.290090405