Reduced glomerular filtration and elevated urinary protein excretion in diabetic ketoacidosis

M. Miltenyi, A. Szabo, T. Tulassay, A. Korner, E. Kenesei, M. Dobos

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Glomerular filtration rate (GFR) was measured by two methods in 9 children with diabetic ketoacidosis (DKA), directly by true creatinine clearance and indirectly by means of serum beta-2-microglobulin levels. We found significantly reduced GFR in the first hours of DKA. The rapid improvement in GFR after fluid and electrolyte replacement indicates that volume depletion is the major cause of low filtration rate. In spite of the reduced GFR we observed pronounced albuminuria and low molecular weight (LMW) proteinuria. We conclude that the pathological albuminuria and microalbuminuria in DKA are caused not by glomerular hyperfiltration but by tubular dysfunction.

Original languageEnglish
Pages (from-to)444-447
Number of pages4
JournalActa Paediatrica Scandinavica
Volume79
Issue number4
DOIs
Publication statusPublished - 1990

Keywords

  • GFR in diabetic ketoacidosis
  • Tubular dysfunction in IDDM

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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