Reduced fronto-cortical brain connectivity during NREM sleep in Asperger syndrome: An EEG spectral and phase coherence study

Alpár Sándor Lázár, Zsolt Iosif Lázár, Andrea Bíró, Miklós Gyori, Zsanett Tárnok, Csilla Prekop, András Keszei, Krisztina Stefanik, Júlia Gádoros, Péter Halász, Róbert Bódizs

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective: To investigate whether sleep macrostructure and EEG power spectral density and coherence during NREM sleep are different in Asperger syndrome (AS) compared to typically developing children and adolescents. Methods: Standard all night EEG sleep parameters were obtained from 18 un-medicated subjects with AS and 14 controls (age range: 7.5-21.5 years) after one adaptation night. Spectral, and phase coherence measures were computed for multiple frequency bands during NREM sleep. Results: Sleep latency and wake after sleep onset were increased in AS. Absolute power spectrum density (PSD) was significantly reduced in AS in the alpha, sigma, beta and gamma bands and in all 10 EEG derivations. Relative PSD showed a significant increase in delta and a decrease in the sigma band for frontal, and in beta for centro-temporal derivations. Intrahemispheric coherence measures were markedly lower in AS in the frontal areas, and the right hemisphere over all EEG channels. The most prominent reduction in intrahemispheric coherence was observed over the fronto-central areas in delta, theta, alpha and sigma EEG frequency bands. Conclusion: EEG power spectra and coherence during NREM sleep, in particular in fronto-cortical derivations are different in AS compared to typically developing children and adolescents. Significance: Quantitative analysis of the EEG during NREM sleep supports the hypothesis of frontal dysfunction in AS.

Original languageEnglish
Pages (from-to)1844-1854
Number of pages11
JournalClinical Neurophysiology
Volume121
Issue number11
DOIs
Publication statusPublished - Nov 1 2010

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Keywords

  • Asperger syndrome
  • Frontal lobe
  • Neural connectivity
  • Phase coherence
  • Polysomnography
  • Power spectrum density

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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