Reduced cardiac vagal excitability in hyperthyroidism

Balazs Kollai, M. Kollai

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A great deal of uncertainty persists regarding the exact nature of the interaction between autonomic nervous activity and thyroid hormones in the control of heart rate. In the present work we investigated whether reduced vagal influence could contribute to the tachycardia in hyperthyroidism. Vagal excitability was studied in ten hyperthyroid patients. Prolongation of R-R interval in response to carotid baroreceptor stimulation by neck suction was found to be less in the hyperthyroid state compared to the control state after therapy. The extent of nocturnal bradycardia and the vagal excitatory response to the central effect of low dose atropin was significantly reduced in hyperthyroid patients compared to euthyroid controls. We concluded that in the hyperthyroid state cardiac vagal motoneurones were in a low excitability state, and speculated that the inhibition might have resulted from thyroid hormone action on CNS structures integrating autonomic function and behaviour.

Original languageEnglish
Pages (from-to)785-790
Number of pages6
JournalBrain Research Bulletin
Volume20
Issue number6
DOIs
Publication statusPublished - 1988

Fingerprint

Hyperthyroidism
Thyroid Hormones
Pressoreceptors
Suction
Motor Neurons
Bradycardia
Tachycardia
Uncertainty
Neck
Heart Rate

Keywords

  • Cardiac baroreflex
  • Cardiac vagal control
  • Hyperthyroidism
  • Tachycardia
  • Thyroid hormones
  • Vagal excitability

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reduced cardiac vagal excitability in hyperthyroidism. / Kollai, Balazs; Kollai, M.

In: Brain Research Bulletin, Vol. 20, No. 6, 1988, p. 785-790.

Research output: Contribution to journalArticle

Kollai, Balazs ; Kollai, M. / Reduced cardiac vagal excitability in hyperthyroidism. In: Brain Research Bulletin. 1988 ; Vol. 20, No. 6. pp. 785-790.
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