Redox status of dogs with non-hodgkin lymphomas. An ESR study

Péter Vajdovich, Tamás Kriska, Miklós Mézes, Piroska Ribiczey Szabó, Nándor Balogh, András Bánfi, Attila Arany-Tóth, Tibor Gaál, Judit Jakus

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14 Citations (Scopus)

Abstract

Free radical and antioxidant parameters in healthy dogs (n=10) and dogs with non-Hodgkin lymphomas (n=11) were measured in blood and lymph node tissue samples before chemotherapy. Enzymatic and other biochemical measurements were performed. We found that (i) free radical concentrations based on ESR spectra of tissues correlated with higher proliferative character; (ii) lymphoma cases showed an impaired antioxidant status; (iii) tumors with low oxidative burst capacity and higher reduced/oxidized glutathione ratio responded better to chemotherapy; and (iv) affected blood and lymph nodes were under strong oxidative stress.

Original languageEnglish
Pages (from-to)339-346
Number of pages8
JournalCancer Letters
Volume224
Issue number2
DOIs
Publication statusPublished - Jun 28 2005

Keywords

  • Antioxidant
  • Canine lymphoma
  • Free radicals
  • MDR
  • Oxidative burst
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Vajdovich, P., Kriska, T., Mézes, M., Szabó, P. R., Balogh, N., Bánfi, A., Arany-Tóth, A., Gaál, T., & Jakus, J. (2005). Redox status of dogs with non-hodgkin lymphomas. An ESR study. Cancer Letters, 224(2), 339-346. https://doi.org/10.1016/j.canlet.2004.11.037