Redox status and expression of chemokines in the rat lungs on exposure to asbestos and asbestos substituents

Erzsébet Tátrai, Márta Brózik, Zuzana Kováčiková

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Activity of cytoplasmatic superoxide dismutase, glutathione peroxidase,-and reductase, γ-glutamyl transpeptidase and expression of macrophage chemoattractant protein-1 and macrophage inhibitory protein-1α was determined in primary culture of rat alveolar macrophages and type II pneumocytes after exposure to stone-wool, wollastonite and crocidolite (blue asbestos). Methods: The activity of redox enzymes was examined by RANDOX kits, chemokines were studied by ELISA. Results: The UICC crocidolite (positive control) decreased the activity of all redox enzymes and increased the expression of chemokines, whereas the two asbestos substituents did not alter the activity of redox enzymes either in the alveolar macrophages or pneumocytes. Stone-wool and wollastonite moderately increased the expression of chemokines in both cells. Conclusions: The redox status and production of chemokines changed in the opposite direction, presumably owing to stronger toxic effect of asbestos. These data suggest that stone-wool and wollastonite, as potential substituents for asbestos, are less toxic than the human carcinogenic and fibrogenic crocidolite.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalNeuroendocrinology Letters
Volume27
Issue numberSUPPL. 2
Publication statusPublished - Dec 1 2006

Keywords

  • Asbestos substituents
  • Glutathione peroxidase, reductase
  • Macrophage chemoattractant protein-1
  • Macrophage inhibitory protein-1α
  • Pneumocytes type II
  • Pulmonary alveolar macrophages
  • Superoxide dismutase
  • γ-glutamyl transpeptidase

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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