Redox state potential influences (±)Δ[Na+]o activity values during acetylcholine contractures of frog skeletal muscles

A. Puppi, I. Wittmann, M. Dely

Research output: Contribution to journalArticle

Abstract

1. 1. The slow alterations in the activity of extracellular Na+ concentrations were measured by using ion-selective electrodes. 2. 2. In the first min there is an increase in the changes of the activity of extracellular Na+ following acetylcholine evoked contractures. 3. 3. This increment was significantly inhibited by k-Strophantoside application, suggesting an active transport origin of this first peak. 4. 4. In the second min a strong decrease in the activity of extracellular Na+ concentration followed. 5. 5. Reducing agent (ascorbate) increased, while oxidant (methylene-blue) decreased both the first increment and the sequential decrement in the activity of the extracellular Na+ concentrations. 6. 6. On the basis of these experiments a site of action of the redox regulation of excitatory processes could be the modification of Na+ fluxes.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalGeneral Pharmacology
Volume13
Issue number4
DOIs
Publication statusPublished - 1982

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Ion-Selective Electrodes
Active Biological Transport
Methylene Blue
Reducing Agents
Contracture
Oxidants
Anura
Acetylcholine
Oxidation-Reduction
Skeletal Muscle

ASJC Scopus subject areas

  • Pharmacology

Cite this

Redox state potential influences (±)Δ[Na+]o activity values during acetylcholine contractures of frog skeletal muscles. / Puppi, A.; Wittmann, I.; Dely, M.

In: General Pharmacology, Vol. 13, No. 4, 1982, p. 321-325.

Research output: Contribution to journalArticle

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