Redox regulation of stem cell mobilization

I. Lekli, Narasimman Gurusamy, Diptarka Ray, A. Tósaki, Dipak K. Das

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A growing body of evidence supposts the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)1α appears to play a significant role in their maintenance and homing mechanism.

Original languageEnglish
Pages (from-to)989-995
Number of pages7
JournalCanadian Journal of Physiology and Pharmacology
Volume87
Issue number12
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Hematopoietic Stem Cell Mobilization
Oxidation-Reduction
Stem Cells
Hypoxia-Inducible Factor 1
Cell Differentiation
Homeostasis
Maintenance
Cytokines
Oxygen
Growth
Proteins
Hypoxia

Keywords

  • Cytokines
  • FoxO
  • Hematopoietic stem cells
  • HIP-1α
  • Redox signaling
  • SirT
  • Stem cell homing

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Pharmacology

Cite this

Redox regulation of stem cell mobilization. / Lekli, I.; Gurusamy, Narasimman; Ray, Diptarka; Tósaki, A.; Das, Dipak K.

In: Canadian Journal of Physiology and Pharmacology, Vol. 87, No. 12, 12.2009, p. 989-995.

Research output: Contribution to journalArticle

Lekli, I. ; Gurusamy, Narasimman ; Ray, Diptarka ; Tósaki, A. ; Das, Dipak K. / Redox regulation of stem cell mobilization. In: Canadian Journal of Physiology and Pharmacology. 2009 ; Vol. 87, No. 12. pp. 989-995.
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