Redox control of cancer cell destruction

Csaba Hegedűs, Katalin Kovács, Zsuzsanna Polgár, Zsolt Regdon, Éva Szabó, Agnieszka Robaszkiewicz, Henry Jay Forman, Anna Martner, László Virág

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Redox regulation has been proposed to control various aspects of carcinogenesis, cancer cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As cancer has many faces, the role of redox control in different cancers and in the numerous cancer-related processes often point in different directions. In this review, we focus on the redox control mechanisms of tumor cell destruction. The review covers the tumor-intrinsic role of oxidants derived from the reduction of oxygen and nitrogen in the control of tumor cell proliferation as well as the roles of oxidants and antioxidant systems in cancer cell death caused by traditional anticancer weapons (chemotherapeutic agents, radiotherapy, photodynamic therapy). Emphasis is also put on the role of oxidants and redox status in the outcome following interactions between cancer cells, cytotoxic lymphocytes and tumor infiltrating macrophages.

Original languageEnglish
Pages (from-to)59-74
Number of pages16
JournalRedox Biology
Volume16
DOIs
Publication statusPublished - Jun 2018

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Keywords

  • Antioxidants
  • Cancer
  • Chemotherapeutics
  • Cytotoxic lymphocytes
  • Free radicals
  • Natural killer cells
  • Redox regulation

ASJC Scopus subject areas

  • Organic Chemistry
  • Clinical Biochemistry

Cite this

Hegedűs, C., Kovács, K., Polgár, Z., Regdon, Z., Szabó, É., Robaszkiewicz, A., Forman, H. J., Martner, A., & Virág, L. (2018). Redox control of cancer cell destruction. Redox Biology, 16, 59-74. https://doi.org/10.1016/j.redox.2018.01.015