Red sludge-induced mRNA and miRNA expression alterations in vital organs of CBA/Ca mice

Antal Tibold, Krisztina Juhász, Katalin Gombos, Katalin Gocze, István Ember

Research output: Contribution to journalArticle

Abstract

Several studies have investigated the ecological and genotoxic effects of the red mud accident in 2010 in Ajka, Hungary, but none was designed to reveal the early biological effects of red mud exposure at the level of early-responding gene expression. To address relevant questions, in the present study expression alterations of oncogenes (c-myc, K-ras), tumor suppressor genes (Bcl2, p53) and apoptosis-regulatory micro(mi) RNAs (miR-21, miR-27a, miR-93, miR-221) were analized 1, 3, 6 and 24 h after a single intraperitoneal injection of red mud to CBA/Ca mice. We observed changes in the expression of all investigated mRNAs, miR-21 and miR-221 in the liver, spleen, lung, kidney and lymph nodes of mice. An overexpression of the investigated genes was observed, but the level and the peak of the alteration differed according to examined tissue.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalIn Vivo
Volume28
Issue number1
Publication statusPublished - Jan 1 2014

Keywords

  • Early biological effect
  • Gene expression
  • MicroRNA.
  • Red mud

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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    Tibold, A., Juhász, K., Gombos, K., Gocze, K., & Ember, I. (2014). Red sludge-induced mRNA and miRNA expression alterations in vital organs of CBA/Ca mice. In Vivo, 28(1), 55-60.