Recurrent mossy fibers preferentially innervate parvalbumin-immunoreactive interneurons in the granule cell layer of the rat dentate gyrus

J. M. Blasco-Ibanez, F. J. Martinez-Guijarro, T. F. Freund

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Detection of vesicular zinc and immunohistochemistry against markers for different interneuron subsets were combined to study the postsynaptic target selection of zinc-containing recurrent mossy fiber collaterals in the dentate gyrus. Mossy fiber collaterals in the granule cell layer selectively innervated parvalbumin-containing cells, with numerous contacts per cell, whereas the granule cells were avoided. Under the electron microscope, those boutons made asymmetrical contacts on dendrites and somata. These findings suggest that, in addition to the hilar perforant path-associated (HIPP) interneurons, the basket and chandelier cells also receive a powerful feed-back drive from the granule cells, and thereby are able to control population synchrony in the dentate gyrus. On the other hand, the amount of monosynaptic excitatory feed-back among granule cells is shown to be negligible. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)3219-3225
Number of pages7
JournalNeuroreport
Volume11
Issue number14
DOIs
Publication statusPublished - Oct 28 2000

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Keywords

  • Basket cell
  • Dentate gyrus
  • Granule cells
  • Hippocampus
  • Mossy fibers
  • Zn detection

ASJC Scopus subject areas

  • Neuroscience(all)

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