Recurrent arterial thrombosis associated with the antithrombin basel variant and elevated lipoprotein(a) plasma level in an adolescent patient

Szabolcs Szilágyi, Andrea Péter, M. Magyar, Sándor Balogh, Z. Bereczky

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Both myocardial infarction and ischemic stroke are rare in the young. Yet a 15-year-old male patient suffered a myocardial infarction and later an ischemic stroke despite uninterrupted antiplatelet therapy. His medical history involved the surgical correction of an incomplete atrioventricular canal defect at the age of 13 years. No cardiovascular risk factors other than elevated lipoprotein(a) level could be identified. His antithrombin (AT) activity was decreased and DNA sequence analysis revealed heterozygosity for AT Basel (p.Pro41Leu), a variant with impaired heparin binding. This report supports a possible additional pathophysiological role for AT Basel and elevated lipoprotein(a) level in arterial thrombogenesis.

Original languageEnglish
Pages (from-to)276-279
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume34
Issue number4
DOIs
Publication statusPublished - May 2012

Fingerprint

Lipoprotein(a)
Antithrombins
Thrombosis
Stroke
Myocardial Infarction
DNA Sequence Analysis
Heparin
Therapeutics

Keywords

  • Antithrombin Basel
  • arterial thrombosis
  • Ischemic stroke
  • Lipoprotein(a)
  • Myocardial infarction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Recurrent arterial thrombosis associated with the antithrombin basel variant and elevated lipoprotein(a) plasma level in an adolescent patient. / Szilágyi, Szabolcs; Péter, Andrea; Magyar, M.; Balogh, Sándor; Bereczky, Z.

In: Journal of Pediatric Hematology/Oncology, Vol. 34, No. 4, 05.2012, p. 276-279.

Research output: Contribution to journalArticle

@article{951fe17e74a142a786efa9829d3d57e3,
title = "Recurrent arterial thrombosis associated with the antithrombin basel variant and elevated lipoprotein(a) plasma level in an adolescent patient",
abstract = "Both myocardial infarction and ischemic stroke are rare in the young. Yet a 15-year-old male patient suffered a myocardial infarction and later an ischemic stroke despite uninterrupted antiplatelet therapy. His medical history involved the surgical correction of an incomplete atrioventricular canal defect at the age of 13 years. No cardiovascular risk factors other than elevated lipoprotein(a) level could be identified. His antithrombin (AT) activity was decreased and DNA sequence analysis revealed heterozygosity for AT Basel (p.Pro41Leu), a variant with impaired heparin binding. This report supports a possible additional pathophysiological role for AT Basel and elevated lipoprotein(a) level in arterial thrombogenesis.",
keywords = "Antithrombin Basel, arterial thrombosis, Ischemic stroke, Lipoprotein(a), Myocardial infarction",
author = "Szabolcs Szil{\'a}gyi and Andrea P{\'e}ter and M. Magyar and S{\'a}ndor Balogh and Z. Bereczky",
year = "2012",
month = "5",
doi = "10.1097/MPH.0b013e3182331ecd",
language = "English",
volume = "34",
pages = "276--279",
journal = "Journal of Pediatric Hematology/Oncology",
issn = "1077-4114",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Recurrent arterial thrombosis associated with the antithrombin basel variant and elevated lipoprotein(a) plasma level in an adolescent patient

AU - Szilágyi, Szabolcs

AU - Péter, Andrea

AU - Magyar, M.

AU - Balogh, Sándor

AU - Bereczky, Z.

PY - 2012/5

Y1 - 2012/5

N2 - Both myocardial infarction and ischemic stroke are rare in the young. Yet a 15-year-old male patient suffered a myocardial infarction and later an ischemic stroke despite uninterrupted antiplatelet therapy. His medical history involved the surgical correction of an incomplete atrioventricular canal defect at the age of 13 years. No cardiovascular risk factors other than elevated lipoprotein(a) level could be identified. His antithrombin (AT) activity was decreased and DNA sequence analysis revealed heterozygosity for AT Basel (p.Pro41Leu), a variant with impaired heparin binding. This report supports a possible additional pathophysiological role for AT Basel and elevated lipoprotein(a) level in arterial thrombogenesis.

AB - Both myocardial infarction and ischemic stroke are rare in the young. Yet a 15-year-old male patient suffered a myocardial infarction and later an ischemic stroke despite uninterrupted antiplatelet therapy. His medical history involved the surgical correction of an incomplete atrioventricular canal defect at the age of 13 years. No cardiovascular risk factors other than elevated lipoprotein(a) level could be identified. His antithrombin (AT) activity was decreased and DNA sequence analysis revealed heterozygosity for AT Basel (p.Pro41Leu), a variant with impaired heparin binding. This report supports a possible additional pathophysiological role for AT Basel and elevated lipoprotein(a) level in arterial thrombogenesis.

KW - Antithrombin Basel

KW - arterial thrombosis

KW - Ischemic stroke

KW - Lipoprotein(a)

KW - Myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=84860761481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860761481&partnerID=8YFLogxK

U2 - 10.1097/MPH.0b013e3182331ecd

DO - 10.1097/MPH.0b013e3182331ecd

M3 - Article

C2 - 22134617

AN - SCOPUS:84860761481

VL - 34

SP - 276

EP - 279

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

SN - 1077-4114

IS - 4

ER -