Recurrence of primary sclerosing cholangitis after liver transplantation-The Hungarian experience

Fanni Gelley, Gergely Zádori, Dénes Görög, László Kóbori, Imre Fehérvári, György Gámán, Zsuzsanna Gerlei, Péter Nagy, Eniko Sárváry, Balázs Nemes

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7 Citations (Scopus)

Abstract

Introduction: Recurrence of primary sclerosing cholangitis (rPSC) after liver transplantation (OLT) signifi cantly aff ects longterm graft survival. We aimed to evaluate the incidence of rPSC and clinical data of these patients in Hungary. Patients and Methods: We retrospectively analyzed data of 511 whole liver transplantations from 1995 to 2011. During the study period, 49 OLTs were performed in 43 adult patients with end-stage PSC (10%). Results: Out of 49 OLT, 24 cases were excluded, rPSC was diagnosed in six patients (12%). Patients with rPSC had signifi cantly higher mortality (p = 0.009) and graft loss (p = 0.009) in comparison to patients without recurrent disease. Younger recipient age, higher donor BMI was observed in the rPSC group. One patient was diagnosed with de novo IBD, the remaining fi ve patients had worsening IBD activity in the posttransplant period. PreOLT colectomy was performed in 21% of the control and none of the rPSC group. PostOLT colectomy was performed in two rPSC patients due to severe therapy resistant colitis. Conclusions: Recurrent PSC signifi cantly aff ects long-term mortality and graft loss. Younger age at OLT, higher donor BMI and severe active IBD may be associated with PSC recurrence. PreOLT total colectomy might have protective eff ect against rPSC.

Original languageEnglish
Pages (from-to)16-18
Number of pages3
JournalInterventional Medicine and Applied Science
Volume6
Issue number1
DOIs
Publication statusPublished - Mar 1 2014

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Keywords

  • disease recurrence
  • inflammatory bowel disease
  • liver transplantation
  • primary sclerosing cholangitis

ASJC Scopus subject areas

  • Medicine(all)

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