Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG

Izabella Obál, Judit Soós Katalin Jakab, L. Siklós, J. Engelhardt

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Mice were injected i.p. with IgG samples of different patients to test whether IgG from amyotrophic lateral sclerosis (ALS) can initiate an immune/inflammatory reaction targeting motor neurons. All IgG samples of five ALS patients and none of the disease controls recruited activated microglia cells in the ventral horn of the spinal cord. CD3 lymphocytes were not accumulated in the same tissue. Similar reaction was evoked by injection of IgG from guinea pigs with experimental autoimmune gray matter disease (EAGMD) induced by immunization with the homogenate of the ventral horn of bovine spinal cord. The results indicate that ALS IgG and anti-motoneuron IgG induce microglia reaction targeting motor neurons without initiating T cell response in the recipient mice.

Original languageEnglish
Pages (from-to)2449-2452
Number of pages4
JournalNeuroReport
Volume12
Issue number11
Publication statusPublished - Aug 8 2001

Fingerprint

Amyotrophic Lateral Sclerosis
Microglia
Spinal Cord
Immunoglobulin G
Motor Neurons
Anterior Horn Cells
Immunization
Guinea Pigs
Lymphocytes
T-Lymphocytes
Injections
Spinal Cord Ventral Horn

Keywords

  • ALS
  • IgG
  • Microglia
  • Motor neuron

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG. / Obál, Izabella; Jakab, Judit Soós Katalin; Siklós, L.; Engelhardt, J.

In: NeuroReport, Vol. 12, No. 11, 08.08.2001, p. 2449-2452.

Research output: Contribution to journalArticle

Obál, Izabella ; Jakab, Judit Soós Katalin ; Siklós, L. ; Engelhardt, J. / Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG. In: NeuroReport. 2001 ; Vol. 12, No. 11. pp. 2449-2452.
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