Reconstruction and Simulation of Neocortical Microcircuitry

Henry Markram, Eilif Muller, Srikanth Ramaswamy, Michael W. Reimann, Marwan Abdellah, Carlos Aguado Sanchez, Anastasia Ailamaki, Lidia Alonso-Nanclares, Nicolas Antille, Selim Arsever, Guy Antoine Atenekeng Kahou, Thomas K. Berger, Ahmet Bilgili, Nenad Buncic, Athanassia Chalimourda, Giuseppe Chindemi, Jean Denis Courcol, Fabien Delalondre, Vincent Delattre, Shaul Druckmann & 62 others Raphael Dumusc, James Dynes, Stefan Eilemann, Eyal Gal, Michael Emiel Gevaert, Jean Pierre Ghobril, Albert Gidon, Joe W. Graham, Anirudh Gupta, Valentin Haenel, Etay Hay, Thomas Heinis, Juan B. Hernando, Michael Hines, Lida Kanari, Daniel Keller, John Kenyon, Georges Khazen, Yihwa Kim, James G. King, Z. Kisvárday, Pramod Kumbhar, Sébastien Lasserre, Jean Vincent Le Bé, Bruno R C Magalhães, Angel Merchán-Pérez, Julie Meystre, Benjamin Roy Morrice, Jeffrey Muller, Alberto Muñoz-Céspedes, Shruti Muralidhar, Keerthan Muthurasa, Daniel Nachbaur, Taylor H. Newton, Max Nolte, Aleksandr Ovcharenko, Juan Palacios, Luis Pastor, Rodrigo Perin, Rajnish Ranjan, Imad Riachi, José Rodrigo Rodríguez, Juan Luis Riquelme, Christian Rössert, Konstantinos Sfyrakis, Ying Shi, Julian C. Shillcock, Gilad Silberberg, Ricardo Silva, Farhan Tauheed, Martin Telefont, Maria Toledo-Rodriguez, Thomas Tränkler, Werner Van Geit, Jafet Villafranca Díaz, Richard Walker, Yun Wang, Stefano M. Zaninetta, Javier Defelipe, Sean L. Hill, Idan Segev, Felix Schürmann

Research output: Contribution to journalArticle

357 Citations (Scopus)

Abstract

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm3 containing ∼31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ∼8 million connections with ∼37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies. PaperClip Video Abstract

Original languageEnglish
Pages (from-to)456-492
Number of pages37
JournalCell
Volume163
Issue number2
DOIs
Publication statusPublished - Oct 8 2015

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Synapses
Neurons
Somatosensory Cortex
Physiology
Clamping devices
Automatic Data Processing
Rats
Anatomy
Tuning
Experiments
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., ... Schürmann, F. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell, 163(2), 456-492. https://doi.org/10.1016/j.cell.2015.09.029

Reconstruction and Simulation of Neocortical Microcircuitry. / Markram, Henry; Muller, Eilif; Ramaswamy, Srikanth; Reimann, Michael W.; Abdellah, Marwan; Sanchez, Carlos Aguado; Ailamaki, Anastasia; Alonso-Nanclares, Lidia; Antille, Nicolas; Arsever, Selim; Kahou, Guy Antoine Atenekeng; Berger, Thomas K.; Bilgili, Ahmet; Buncic, Nenad; Chalimourda, Athanassia; Chindemi, Giuseppe; Courcol, Jean Denis; Delalondre, Fabien; Delattre, Vincent; Druckmann, Shaul; Dumusc, Raphael; Dynes, James; Eilemann, Stefan; Gal, Eyal; Gevaert, Michael Emiel; Ghobril, Jean Pierre; Gidon, Albert; Graham, Joe W.; Gupta, Anirudh; Haenel, Valentin; Hay, Etay; Heinis, Thomas; Hernando, Juan B.; Hines, Michael; Kanari, Lida; Keller, Daniel; Kenyon, John; Khazen, Georges; Kim, Yihwa; King, James G.; Kisvárday, Z.; Kumbhar, Pramod; Lasserre, Sébastien; Le Bé, Jean Vincent; Magalhães, Bruno R C; Merchán-Pérez, Angel; Meystre, Julie; Morrice, Benjamin Roy; Muller, Jeffrey; Muñoz-Céspedes, Alberto; Muralidhar, Shruti; Muthurasa, Keerthan; Nachbaur, Daniel; Newton, Taylor H.; Nolte, Max; Ovcharenko, Aleksandr; Palacios, Juan; Pastor, Luis; Perin, Rodrigo; Ranjan, Rajnish; Riachi, Imad; Rodríguez, José Rodrigo; Riquelme, Juan Luis; Rössert, Christian; Sfyrakis, Konstantinos; Shi, Ying; Shillcock, Julian C.; Silberberg, Gilad; Silva, Ricardo; Tauheed, Farhan; Telefont, Martin; Toledo-Rodriguez, Maria; Tränkler, Thomas; Van Geit, Werner; Díaz, Jafet Villafranca; Walker, Richard; Wang, Yun; Zaninetta, Stefano M.; Defelipe, Javier; Hill, Sean L.; Segev, Idan; Schürmann, Felix.

In: Cell, Vol. 163, No. 2, 08.10.2015, p. 456-492.

Research output: Contribution to journalArticle

Markram, H, Muller, E, Ramaswamy, S, Reimann, MW, Abdellah, M, Sanchez, CA, Ailamaki, A, Alonso-Nanclares, L, Antille, N, Arsever, S, Kahou, GAA, Berger, TK, Bilgili, A, Buncic, N, Chalimourda, A, Chindemi, G, Courcol, JD, Delalondre, F, Delattre, V, Druckmann, S, Dumusc, R, Dynes, J, Eilemann, S, Gal, E, Gevaert, ME, Ghobril, JP, Gidon, A, Graham, JW, Gupta, A, Haenel, V, Hay, E, Heinis, T, Hernando, JB, Hines, M, Kanari, L, Keller, D, Kenyon, J, Khazen, G, Kim, Y, King, JG, Kisvárday, Z, Kumbhar, P, Lasserre, S, Le Bé, JV, Magalhães, BRC, Merchán-Pérez, A, Meystre, J, Morrice, BR, Muller, J, Muñoz-Céspedes, A, Muralidhar, S, Muthurasa, K, Nachbaur, D, Newton, TH, Nolte, M, Ovcharenko, A, Palacios, J, Pastor, L, Perin, R, Ranjan, R, Riachi, I, Rodríguez, JR, Riquelme, JL, Rössert, C, Sfyrakis, K, Shi, Y, Shillcock, JC, Silberberg, G, Silva, R, Tauheed, F, Telefont, M, Toledo-Rodriguez, M, Tränkler, T, Van Geit, W, Díaz, JV, Walker, R, Wang, Y, Zaninetta, SM, Defelipe, J, Hill, SL, Segev, I & Schürmann, F 2015, 'Reconstruction and Simulation of Neocortical Microcircuitry', Cell, vol. 163, no. 2, pp. 456-492. https://doi.org/10.1016/j.cell.2015.09.029
Markram H, Muller E, Ramaswamy S, Reimann MW, Abdellah M, Sanchez CA et al. Reconstruction and Simulation of Neocortical Microcircuitry. Cell. 2015 Oct 8;163(2):456-492. https://doi.org/10.1016/j.cell.2015.09.029
Markram, Henry ; Muller, Eilif ; Ramaswamy, Srikanth ; Reimann, Michael W. ; Abdellah, Marwan ; Sanchez, Carlos Aguado ; Ailamaki, Anastasia ; Alonso-Nanclares, Lidia ; Antille, Nicolas ; Arsever, Selim ; Kahou, Guy Antoine Atenekeng ; Berger, Thomas K. ; Bilgili, Ahmet ; Buncic, Nenad ; Chalimourda, Athanassia ; Chindemi, Giuseppe ; Courcol, Jean Denis ; Delalondre, Fabien ; Delattre, Vincent ; Druckmann, Shaul ; Dumusc, Raphael ; Dynes, James ; Eilemann, Stefan ; Gal, Eyal ; Gevaert, Michael Emiel ; Ghobril, Jean Pierre ; Gidon, Albert ; Graham, Joe W. ; Gupta, Anirudh ; Haenel, Valentin ; Hay, Etay ; Heinis, Thomas ; Hernando, Juan B. ; Hines, Michael ; Kanari, Lida ; Keller, Daniel ; Kenyon, John ; Khazen, Georges ; Kim, Yihwa ; King, James G. ; Kisvárday, Z. ; Kumbhar, Pramod ; Lasserre, Sébastien ; Le Bé, Jean Vincent ; Magalhães, Bruno R C ; Merchán-Pérez, Angel ; Meystre, Julie ; Morrice, Benjamin Roy ; Muller, Jeffrey ; Muñoz-Céspedes, Alberto ; Muralidhar, Shruti ; Muthurasa, Keerthan ; Nachbaur, Daniel ; Newton, Taylor H. ; Nolte, Max ; Ovcharenko, Aleksandr ; Palacios, Juan ; Pastor, Luis ; Perin, Rodrigo ; Ranjan, Rajnish ; Riachi, Imad ; Rodríguez, José Rodrigo ; Riquelme, Juan Luis ; Rössert, Christian ; Sfyrakis, Konstantinos ; Shi, Ying ; Shillcock, Julian C. ; Silberberg, Gilad ; Silva, Ricardo ; Tauheed, Farhan ; Telefont, Martin ; Toledo-Rodriguez, Maria ; Tränkler, Thomas ; Van Geit, Werner ; Díaz, Jafet Villafranca ; Walker, Richard ; Wang, Yun ; Zaninetta, Stefano M. ; Defelipe, Javier ; Hill, Sean L. ; Segev, Idan ; Schürmann, Felix. / Reconstruction and Simulation of Neocortical Microcircuitry. In: Cell. 2015 ; Vol. 163, No. 2. pp. 456-492.
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AU - Muller, Eilif

AU - Ramaswamy, Srikanth

AU - Reimann, Michael W.

AU - Abdellah, Marwan

AU - Sanchez, Carlos Aguado

AU - Ailamaki, Anastasia

AU - Alonso-Nanclares, Lidia

AU - Antille, Nicolas

AU - Arsever, Selim

AU - Kahou, Guy Antoine Atenekeng

AU - Berger, Thomas K.

AU - Bilgili, Ahmet

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AU - Hay, Etay

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AU - Meystre, Julie

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AU - Muñoz-Céspedes, Alberto

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AU - Muthurasa, Keerthan

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AU - Newton, Taylor H.

AU - Nolte, Max

AU - Ovcharenko, Aleksandr

AU - Palacios, Juan

AU - Pastor, Luis

AU - Perin, Rodrigo

AU - Ranjan, Rajnish

AU - Riachi, Imad

AU - Rodríguez, José Rodrigo

AU - Riquelme, Juan Luis

AU - Rössert, Christian

AU - Sfyrakis, Konstantinos

AU - Shi, Ying

AU - Shillcock, Julian C.

AU - Silberberg, Gilad

AU - Silva, Ricardo

AU - Tauheed, Farhan

AU - Telefont, Martin

AU - Toledo-Rodriguez, Maria

AU - Tränkler, Thomas

AU - Van Geit, Werner

AU - Díaz, Jafet Villafranca

AU - Walker, Richard

AU - Wang, Yun

AU - Zaninetta, Stefano M.

AU - Defelipe, Javier

AU - Hill, Sean L.

AU - Segev, Idan

AU - Schürmann, Felix

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