Reconstructing Roma History from Genome-Wide Data

Priya Moorjani, Nick Patterson, Po Ru Loh, Mark Lipson, P. Kisfali, Bela I. Melegh, Michael Bonin, Ľudevít Kádaši, Olaf Rieß, Bonnie Berger, David Reich, B. Melegh

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The Roma people, living throughout Europe and West Asia, are a diverse population linked by the Romani language and culture. Previous linguistic and genetic studies have suggested that the Roma migrated into Europe from South Asia about 1,000-1,500 years ago. Genetic inferences about Roma history have mostly focused on the Y chromosome and mitochondrial DNA. To explore what additional information can be learned from genome-wide data, we analyzed data from six Roma groups that we genotyped at hundreds of thousands of single nucleotide polymorphisms (SNPs). We estimate that the Roma harbor about 80% West Eurasian ancestry-derived from a combination of European and South Asian sources-and that the date of admixture of South Asian and European ancestry was about 850 years before present. We provide evidence for Eastern Europe being a major source of European ancestry, and North-west India being a major source of the South Asian ancestry in the Roma. By computing allele sharing as a measure of linkage disequilibrium, we estimate that the migration of Roma out of the Indian subcontinent was accompanied by a severe founder event, which appears to have been followed by a major demographic expansion after the arrival in Europe.

Original languageEnglish
Article numbere58633
JournalPLoS One
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 13 2013

Fingerprint

Roma
Chromosomes
Ports and harbors
Polymorphism
Mitochondrial DNA
Linguistics
ancestry
Nucleotides
Genes
Genome
history
genome
West Asia
South Asia
Eastern European region
Y chromosome
linkage disequilibrium
single nucleotide polymorphism
mitochondrial DNA
demographic statistics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Moorjani, P., Patterson, N., Loh, P. R., Lipson, M., Kisfali, P., Melegh, B. I., ... Melegh, B. (2013). Reconstructing Roma History from Genome-Wide Data. PLoS One, 8(3), [e58633]. https://doi.org/10.1371/journal.pone.0058633

Reconstructing Roma History from Genome-Wide Data. / Moorjani, Priya; Patterson, Nick; Loh, Po Ru; Lipson, Mark; Kisfali, P.; Melegh, Bela I.; Bonin, Michael; Kádaši, Ľudevít; Rieß, Olaf; Berger, Bonnie; Reich, David; Melegh, B.

In: PLoS One, Vol. 8, No. 3, e58633, 13.03.2013.

Research output: Contribution to journalArticle

Moorjani, P, Patterson, N, Loh, PR, Lipson, M, Kisfali, P, Melegh, BI, Bonin, M, Kádaši, Ľ, Rieß, O, Berger, B, Reich, D & Melegh, B 2013, 'Reconstructing Roma History from Genome-Wide Data', PLoS One, vol. 8, no. 3, e58633. https://doi.org/10.1371/journal.pone.0058633
Moorjani P, Patterson N, Loh PR, Lipson M, Kisfali P, Melegh BI et al. Reconstructing Roma History from Genome-Wide Data. PLoS One. 2013 Mar 13;8(3). e58633. https://doi.org/10.1371/journal.pone.0058633
Moorjani, Priya ; Patterson, Nick ; Loh, Po Ru ; Lipson, Mark ; Kisfali, P. ; Melegh, Bela I. ; Bonin, Michael ; Kádaši, Ľudevít ; Rieß, Olaf ; Berger, Bonnie ; Reich, David ; Melegh, B. / Reconstructing Roma History from Genome-Wide Data. In: PLoS One. 2013 ; Vol. 8, No. 3.
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