Reconstitution of liver mass via cellular hypertrophy in the rat

P. Nagy, T. Teramoto, V. M. Factor, A. Sanchez, J. Schnur, S. Paku, S. S. Thorgeirsson

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The liver has an extremely effective regenerative capacity. When 70% of a rat liver is removed by surgery, the liver mass regrows in 7 to 10 days by the compensatory hyperplasia of the remnant part. In case of damage to the surviving hepatocytes, the facultative stem-cell compartment is activated and the liver regenerates by means of oval-cell proliferation/differentiation. In the present study, we demonstrate that when both hepatocyte proliferation and stem-cell activation were prevented by dexamethasone (Dex) administration, the liver mass was restored in the absence of DNA synthesis. The restoration of the liver was accomplished by the preferential enlargement/hypertrophy of the periportal hepatocytes. A similar response was observed when cell proliferation was arrested by 5-fluorouracil (FU) following partial hepatectomy. Therefore, the hepatocytic hypertrophy appears to provide an alternative mechanism of liver-mass restoration. This hypertrophic condition of the liver is not stable, because following the withdrawal of Dex, the enlarged hepatocytes entered in the cell cycle and the normal liver structure and DNA content was re-established.

Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalHepatology
Volume33
Issue number2
DOIs
Publication statusPublished - 2001

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Hypertrophy
Liver
Hepatocytes
Dexamethasone
Stem Cells
Cell Proliferation
DNA
Hepatectomy
Fluorouracil
Hyperplasia
Cell Differentiation
Cell Cycle

ASJC Scopus subject areas

  • Hepatology

Cite this

Nagy, P., Teramoto, T., Factor, V. M., Sanchez, A., Schnur, J., Paku, S., & Thorgeirsson, S. S. (2001). Reconstitution of liver mass via cellular hypertrophy in the rat. Hepatology, 33(2), 339-345. https://doi.org/10.1053/jhep.2001.21326

Reconstitution of liver mass via cellular hypertrophy in the rat. / Nagy, P.; Teramoto, T.; Factor, V. M.; Sanchez, A.; Schnur, J.; Paku, S.; Thorgeirsson, S. S.

In: Hepatology, Vol. 33, No. 2, 2001, p. 339-345.

Research output: Contribution to journalArticle

Nagy, P, Teramoto, T, Factor, VM, Sanchez, A, Schnur, J, Paku, S & Thorgeirsson, SS 2001, 'Reconstitution of liver mass via cellular hypertrophy in the rat', Hepatology, vol. 33, no. 2, pp. 339-345. https://doi.org/10.1053/jhep.2001.21326
Nagy, P. ; Teramoto, T. ; Factor, V. M. ; Sanchez, A. ; Schnur, J. ; Paku, S. ; Thorgeirsson, S. S. / Reconstitution of liver mass via cellular hypertrophy in the rat. In: Hepatology. 2001 ; Vol. 33, No. 2. pp. 339-345.
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