Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

M. Benczur, G. Sármay, T. Laskay, E. Gyódi, G. Petrányi, J. Gergely

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

Original languageEnglish
Pages (from-to)1331-1340
Number of pages10
JournalMolecular Immunology
Volume19
Issue number10
DOIs
Publication statusPublished - 1982

Fingerprint

Natural Killer Cells
Lymphocytes
Neoplasms
Fc Receptors
beta 2-Microglobulin
Histocompatibility Antigens
Population

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells. / Benczur, M.; Sármay, G.; Laskay, T.; Gyódi, E.; Petrányi, G.; Gergely, J.

In: Molecular Immunology, Vol. 19, No. 10, 1982, p. 1331-1340.

Research output: Contribution to journalArticle

@article{49dbf07cef6b408da269dd717e7782e4,
title = "Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells",
abstract = "The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.",
author = "M. Benczur and G. S{\'a}rmay and T. Laskay and E. Gy{\'o}di and G. Petr{\'a}nyi and J. Gergely",
year = "1982",
doi = "10.1016/0161-5890(82)90301-7",
language = "English",
volume = "19",
pages = "1331--1340",
journal = "Molecular Immunology",
issn = "0161-5890",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells

AU - Benczur, M.

AU - Sármay, G.

AU - Laskay, T.

AU - Gyódi, E.

AU - Petrányi, G.

AU - Gergely, J.

PY - 1982

Y1 - 1982

N2 - The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

AB - The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of H LA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK. recognition.

UR - http://www.scopus.com/inward/record.url?scp=0019992672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019992672&partnerID=8YFLogxK

U2 - 10.1016/0161-5890(82)90301-7

DO - 10.1016/0161-5890(82)90301-7

M3 - Article

C2 - 6757725

AN - SCOPUS:0019992672

VL - 19

SP - 1331

EP - 1340

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

IS - 10

ER -