Receptor-mediated interaction between the sympathetic nervous system and immune system in inflammation

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The sympathetic nervous system plays a central role in establishing communication between the central nervous system and the immune system during inflammation. Inflammation activates the sympathetic nervous system, which causes release of the transmitters of the sympathetic nervous system in the periphery. The transmitters of the sympathetic nervous system are the catecholamines noradrenaline and adrenaline and the purines ATP, adenosine, and inosine. Once these transmitters are released, they stimulate both presynaptic receptors on nerve terminals and post-synaptic receptors on immune cells. The receptors that are sensitive to catecholamines are termed adrenoceptors, whereas the receptors that bind purines are called purinoceptors. Stimulation of the presynaptic receptors exerts an autoregulatory effect on the release of transmitters. Ligation of the postsynaptic receptors on inflammatory cells modulates the inflammatory activities of these cells. The present review summarizes some of the most important aspects of the current state of knowledge about the interactions between the sympathetic nervous system and the immune system during inflammation with a special emphasis on the role of adreno and purinoceptors.

Original languageEnglish
Pages (from-to)1039-1044
Number of pages6
JournalNeurochemical Research
Volume26
Issue number8-9
DOIs
Publication statusPublished - 2001

Fingerprint

Immune system
Sympathetic Nervous System
Neurology
Immune System
Purinergic Receptors
Inflammation
Transmitters
Presynaptic Receptors
Catecholamines
Inosine
Purines
Neurotransmitter Receptor
Adenosine
Adrenergic Receptors
Epinephrine
Ligation
Norepinephrine
Central Nervous System
Adenosine Triphosphate
Cells

Keywords

  • Autoimmune disease
  • Brain
  • Immunity
  • Sepsis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Receptor-mediated interaction between the sympathetic nervous system and immune system in inflammation. / Haskó, G.

In: Neurochemical Research, Vol. 26, No. 8-9, 2001, p. 1039-1044.

Research output: Contribution to journalArticle

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