A szervtranszplantációt követo gyógyszeres kezelés újabb lehetoségei

Translated title of the contribution: Recent options in drug therapy after solid organ transplantation

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Solid organ transplantation has shown improvement in patient and graft survival rates due to the development of immunosuppression in the last fifty years; however only the last two decades led to the development of new, baseline immunosuppressive drugs that avoid the unlikely side effects of calcineurin inhibitors, especially nephrotoxicity. The transplanted organ is foreign to the host and, therefore, it induces a complex immune response of the recipient. In this review, a brief outline of immune response is given, followed by the introduction of new immunosuppressive drugs acting via variant pathways. These are compounds which are already in use or becoming shortly available and are potential future alternatives for the calcineurin inhibitors. This paper highlights the role of co-stimulation blockade with belatacept and the recently even more intensively studied field of tolerance induction.

Translated title of the contributionRecent options in drug therapy after solid organ transplantation
Original languageHungarian
Pages (from-to)1294-1301
Number of pages8
JournalOrvosi hetilap
Volume153
Issue number33
DOIs
Publication statusPublished - Aug 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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