The Pestivirus genus in one of the most intensively studied groups of animal viruses. Detailed studies on pestiviruses make necessary also the re-classification of the genus. The recent study has summarized the recent knowledge on the bovine diarrhoea virus (BVDV). Actual taxonomic questions have also been dealt with, namely the two genotypes of BVDV, as well as the new, non host-specific classification of pestiviruses. The morphological and physical characterization of the virus has not been dealt with. Genome structure (Fig.1) genome organization, proteins responsible for the cytopathogenic effect have been discussed according to our present knowledge. The differences between the two biotypes of BVDV - cytopathogenic (cp, Fig.2) and non-cytopathogenic (ncp) viruses - have also been discussed, classifying according to recombinative events suffered by the virus genome. For the time being it seems on the basis of the results of recent research that the recombinative events of the amino-terminal of non-structural p80 enzyme protein of BVDV (Fig.3) are principally responsible for the transformation of ncp BVDV - mainly present in the nature - to cp BVDV and thus to the development of mucosal disease, MD.
|Translated title of the contribution||Recent knowledge on the bovine virus diarrhoea virus review article|
|Number of pages||1|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - Dec 1 1998|
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