Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets

Sándor Berényi, Csaba Csutorás, Attila Sipos

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

The most practical synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material. This review intends to focus on chemical transformations of morphinans which resulted in morphinandiene derivatives with well-established and novel pharmacological potencies. These chemical transformations were mainly associated with the formation and substitution of the unique diene structure of the ring C of the morphinan backbone.

Original languageEnglish
Pages (from-to)3215-3242
Number of pages28
JournalCurrent medicinal chemistry
Volume16
Issue number25
DOIs
Publication statusPublished - Nov 27 2009

Keywords

  • Dopamine activity
  • Morphinandiene
  • Opioid activity
  • Orvinols
  • Thebaine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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