Recent concepts in the management of infertility because of non-obstructive azoospermia

H. Tournaye, M. Camus, A. Goossens, J. Liu, P. Nagy, S. Silber, A. C. Van Steirteghem, P. Devroey

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Testicular biopsy has been widely used for the diagnosis of male infertility. Since the introduction of intracytoplasmic sperm injection (ICSI), spermatozoa recovered from a testicular biopsy specimen can be successfully used for establishing pregnancies. A few spermatozoa may be recovered from a wet preparation of a testicular biopsy, not only in obstructive azoospermic patients, but also in many patients with nonobstructive azoospermia. In 36 out of 38 nonobstructive azoospermic patients sperm cells were recovered from a testicular biopsy specimen. However in two patients, spermatozoa could not be found after further preparation of the biopsy specimens for ICSI. In the remaining 32 patients, a normal fertilization rate of 56.8% per succesfully injected oocyte was obtained after ICSI of testicular spermatozoa. In 84% of patients, embryos were replaced with an overall pregnancy rate of 28.9% per testicular biopsy or 34.3% per embryo transfer. The results clearly indicate that at present an excisional testicular biopsy should be offered to all azoospermic patient, irrespective of concentration of follicle stimulating hormone, testicular size or medical history.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalHuman Reproduction
Volume10
Issue numberSUPPL. 1
Publication statusPublished - 1995

Fingerprint

Azoospermia
Infertility
Biopsy
Spermatozoa
Intracytoplasmic Sperm Injections
Embryo Transfer
Male Infertility
Follicle Stimulating Hormone
Pregnancy Rate
Fertilization
Oocytes
Embryonic Structures
Pregnancy

Keywords

  • Infertility
  • Non-obstructive azoospermia
  • Treatments

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Tournaye, H., Camus, M., Goossens, A., Liu, J., Nagy, P., Silber, S., ... Devroey, P. (1995). Recent concepts in the management of infertility because of non-obstructive azoospermia. Human Reproduction, 10(SUPPL. 1), 115-119.

Recent concepts in the management of infertility because of non-obstructive azoospermia. / Tournaye, H.; Camus, M.; Goossens, A.; Liu, J.; Nagy, P.; Silber, S.; Van Steirteghem, A. C.; Devroey, P.

In: Human Reproduction, Vol. 10, No. SUPPL. 1, 1995, p. 115-119.

Research output: Contribution to journalArticle

Tournaye, H, Camus, M, Goossens, A, Liu, J, Nagy, P, Silber, S, Van Steirteghem, AC & Devroey, P 1995, 'Recent concepts in the management of infertility because of non-obstructive azoospermia', Human Reproduction, vol. 10, no. SUPPL. 1, pp. 115-119.
Tournaye H, Camus M, Goossens A, Liu J, Nagy P, Silber S et al. Recent concepts in the management of infertility because of non-obstructive azoospermia. Human Reproduction. 1995;10(SUPPL. 1):115-119.
Tournaye, H. ; Camus, M. ; Goossens, A. ; Liu, J. ; Nagy, P. ; Silber, S. ; Van Steirteghem, A. C. ; Devroey, P. / Recent concepts in the management of infertility because of non-obstructive azoospermia. In: Human Reproduction. 1995 ; Vol. 10, No. SUPPL. 1. pp. 115-119.
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