Újdonságok a gyermekkori non-Hodgkinlimfóma kezelésében és kivizsgálásában. Szakirodalmi áttekintés és a debreceni gyermekhematológiai központ adatai

Translated title of the contribution: Recent advances in pediatric non-Hodgkin lymphoma. Report on a retrospective single-center cohort and review of the literature

István Szegedi, Imre Gáspár, Katalin Gyurina, Zsuzsa Zele, Csongor Kiss

Research output: Contribution to journalArticle

Abstract

Classification, staging and treatment response criteria of pediatric NHL have been revised. Long-term survival reaches ~90% at the expense of severe acute toxicities. The outcome of refractory and relapsed cases is poor. The small number of patients hinders introduction of targeted therapies. Here we summarize principles and perspectives of pediatric NHL supported by results of a retrospective clinical survey. Twenty-five patients (21 boys, 4 girls; mean age: 11.9 years) were registered between 2009 and 2018: 11 Burkitt lymphomas, 4 diffuse large B-cell lymphomas, 5 T-cell lymphoblastic lymphomas, and 1-1 grey-zone lymphoma, anaplastic large-cell lymphoma, cutaneous T-cell lymphoma, angioimmunoblastic lymphoma, and Castleman disease. Remission rate was 22/25, 20/25 patients survived (mean follow-up time: 3.9 years). Chemotherapies according to NHL-BFM 95, CHOP, FAB/LMB96, Inter-B-NHL Ritux 2010, Euro-LB02, and ALCL99 were applied. Adjuvant immunotherapy was applied in patients with mature B-cell NHL (rituximab in 7 cases, obinutuzumab in 2 relapsed cases). In Castleman disease siltuximab was applied.

Translated title of the contributionRecent advances in pediatric non-Hodgkin lymphoma. Report on a retrospective single-center cohort and review of the literature
Original languageHungarian
Pages (from-to)204-213
Number of pages10
JournalMagyar onkologia
Volume62
Issue number4
Publication statusPublished - Dec 12 2018

ASJC Scopus subject areas

  • Medicine(all)

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