Recent advances in molecular biology of gestational trophoblastic diseases: A review

Vilmos Fulop, Samuel C. Mok, Istvan Gati, Ross S. Berkowitz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Gestational trophoblastic diseases are interrelated conditions characterized by abnormal growth of chorionic tissues with various propensities for local invasion and metastasis. Complete mole is a unique conception in that all nuclear DNA is paternally derived and all cytoplasmic DNA is maternally derived. In contrast, partial mole generally has a triploid karyotype, where the extra haploid set of chromosomes is paternally derived. Gestational trophoblastic diseases are characterized by altered expression of several growth regulatory factors and oncogenes. While differences in expression of oncoproteins may be important to the development of gestational trophoblastic disease, the precise molecular changes that are critical to pathogenesis remain unknown.

Original languageEnglish
Pages (from-to)369-379
Number of pages11
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume47
Issue number5
Publication statusPublished - Jun 4 2002

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Keywords

  • Molecular biology
  • Trophoblastic neoplasms

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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