Recent advances in molecular biology of gestational trophoblastic diseases: A review

V. Fülöp, Samuel C. Mok, Istvan Gati, Ross S. Berkowitz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Gestational trophoblastic diseases are interrelated conditions characterized by abnormal growth of chorionic tissues with various propensities for local invasion and metastasis. Complete mole is a unique conception in that all nuclear DNA is paternally derived and all cytoplasmic DNA is maternally derived. In contrast, partial mole generally has a triploid karyotype, where the extra haploid set of chromosomes is paternally derived. Gestational trophoblastic diseases are characterized by altered expression of several growth regulatory factors and oncogenes. While differences in expression of oncoproteins may be important to the development of gestational trophoblastic disease, the precise molecular changes that are critical to pathogenesis remain unknown.

Original languageEnglish
Pages (from-to)369-379
Number of pages11
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume47
Issue number5
Publication statusPublished - 2002

Fingerprint

Gestational Trophoblastic Disease
Molecular Biology
Triploidy
Haploidy
Oncogene Proteins
DNA
Karyotype
Oncogenes
Intercellular Signaling Peptides and Proteins
Chromosomes
Neoplasm Metastasis
Growth

Keywords

  • Molecular biology
  • Trophoblastic neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Recent advances in molecular biology of gestational trophoblastic diseases : A review. / Fülöp, V.; Mok, Samuel C.; Gati, Istvan; Berkowitz, Ross S.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 47, No. 5, 2002, p. 369-379.

Research output: Contribution to journalArticle

@article{e96b83ce8f804b32accf7f047cbe7975,
title = "Recent advances in molecular biology of gestational trophoblastic diseases: A review",
abstract = "Gestational trophoblastic diseases are interrelated conditions characterized by abnormal growth of chorionic tissues with various propensities for local invasion and metastasis. Complete mole is a unique conception in that all nuclear DNA is paternally derived and all cytoplasmic DNA is maternally derived. In contrast, partial mole generally has a triploid karyotype, where the extra haploid set of chromosomes is paternally derived. Gestational trophoblastic diseases are characterized by altered expression of several growth regulatory factors and oncogenes. While differences in expression of oncoproteins may be important to the development of gestational trophoblastic disease, the precise molecular changes that are critical to pathogenesis remain unknown.",
keywords = "Molecular biology, Trophoblastic neoplasms",
author = "V. F{\"u}l{\"o}p and Mok, {Samuel C.} and Istvan Gati and Berkowitz, {Ross S.}",
year = "2002",
language = "English",
volume = "47",
pages = "369--379",
journal = "The Journal of reproductive medicine",
issn = "0024-7758",
publisher = "Donna Kessel",
number = "5",

}

TY - JOUR

T1 - Recent advances in molecular biology of gestational trophoblastic diseases

T2 - A review

AU - Fülöp, V.

AU - Mok, Samuel C.

AU - Gati, Istvan

AU - Berkowitz, Ross S.

PY - 2002

Y1 - 2002

N2 - Gestational trophoblastic diseases are interrelated conditions characterized by abnormal growth of chorionic tissues with various propensities for local invasion and metastasis. Complete mole is a unique conception in that all nuclear DNA is paternally derived and all cytoplasmic DNA is maternally derived. In contrast, partial mole generally has a triploid karyotype, where the extra haploid set of chromosomes is paternally derived. Gestational trophoblastic diseases are characterized by altered expression of several growth regulatory factors and oncogenes. While differences in expression of oncoproteins may be important to the development of gestational trophoblastic disease, the precise molecular changes that are critical to pathogenesis remain unknown.

AB - Gestational trophoblastic diseases are interrelated conditions characterized by abnormal growth of chorionic tissues with various propensities for local invasion and metastasis. Complete mole is a unique conception in that all nuclear DNA is paternally derived and all cytoplasmic DNA is maternally derived. In contrast, partial mole generally has a triploid karyotype, where the extra haploid set of chromosomes is paternally derived. Gestational trophoblastic diseases are characterized by altered expression of several growth regulatory factors and oncogenes. While differences in expression of oncoproteins may be important to the development of gestational trophoblastic disease, the precise molecular changes that are critical to pathogenesis remain unknown.

KW - Molecular biology

KW - Trophoblastic neoplasms

UR - http://www.scopus.com/inward/record.url?scp=0036108568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036108568&partnerID=8YFLogxK

M3 - Article

C2 - 12063875

AN - SCOPUS:0036108568

VL - 47

SP - 369

EP - 379

JO - The Journal of reproductive medicine

JF - The Journal of reproductive medicine

SN - 0024-7758

IS - 5

ER -