Rearrangement of the T-cell receptor alpha, beta and gamma chain genes in chronic lymphocytic leukemia

Andras Perl, John P. Di Vincenzo, Daniel H. Ryan, Peter Gergely, Agnes Szigeti, J. Fehér, George N. Abraham

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Simultaneous expression of mature B-cell and T-cell markers and subsequent abrogation of expression of the T-cell surface markers by cytotoxic chemotherapy was reported earlier in a patient (TG) with chronic lymphocytic leukemia (CLL). In addition to rearrangements of the immunoglobulin (Ig) gene loci correlating with phenotypic data, the T-cell receptor (TCR) alpha, beta and gamma chain genes also displayed clonal rearrangements in peripheral blood lymphocyte DNA of TG. The present case shows that in CLL cells not only the expression of B-cell and T-cell specific differentiation antigens but also the rearrangement of Ig as well as TCR alpha, beta and gamma genes may occur simultaneously.

Original languageEnglish
JournalLeukemia Research
Volume14
Issue number2
DOIs
Publication statusPublished - 1990

Fingerprint

T-Cell Receptor alpha Genes
T-Cell Receptor gamma Genes
T-Cell Receptor beta Genes
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
T Lymphocyte Differentiation Antigens
T-Lymphocytes
Immunoglobulin Genes
Immunoglobulins
Lymphocytes
Drug Therapy
DNA

Keywords

  • beta
  • CLL
  • gamma gene rearrangements
  • Ig
  • TCR alpha

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Rearrangement of the T-cell receptor alpha, beta and gamma chain genes in chronic lymphocytic leukemia. / Perl, Andras; Di Vincenzo, John P.; Ryan, Daniel H.; Gergely, Peter; Szigeti, Agnes; Fehér, J.; Abraham, George N.

In: Leukemia Research, Vol. 14, No. 2, 1990.

Research output: Contribution to journalArticle

Perl, Andras ; Di Vincenzo, John P. ; Ryan, Daniel H. ; Gergely, Peter ; Szigeti, Agnes ; Fehér, J. ; Abraham, George N. / Rearrangement of the T-cell receptor alpha, beta and gamma chain genes in chronic lymphocytic leukemia. In: Leukemia Research. 1990 ; Vol. 14, No. 2.
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