Gyógyszerhatóanyag-kristályosodás valós idejucombining double acute accent vizsgálata és módosítása segédanyaggal

Translated title of the contribution: Real-time monitoring of drug crystallization with and without additives

H. Pataki, K. Palésti, B. Vajna, I. Csontos, G. Marosi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Crystallization processes can be evaluated from both kinetic and thermodinamic point of view with real-time analitical methods, effects of production parameters on the final quality can be estimated as well. Consequently there is an increasing emphasis on analytical devices being applicable for real-time detection. Among these techniques Raman spectrometry is advantageously utilizable for real-time monitoring of crystallizations. Impurities can dramatically change the nucleation and crystal growth, thus they can alter the physical and chemical properties of the final product. The use of different additives (polymers;surface active ingredients) in the crystallization step in order to modify the product morphology methodically is a new direction in the scientific literature. This study provides an overview of crystallization processes in the presence of additives as well as a summary concerning the monitoring of the drug crystallizations by real-time Raman spectrometry. Furthermore the effect of polyvinyl-pyrrolidone was examined in the course of cooling crystallization of Donepezil HCl, while the process was monitored by in-line Raman spectrometry.

Original languageHungarian
Pages (from-to)109-124
Number of pages16
JournalActa Pharmaceutica Hungarica
Volume81
Issue number3
Publication statusPublished - 2011

Fingerprint

Drug Monitoring
Crystallization
Spectrum Analysis
Polyvinyls
Literature
Pyrrolidinones
Polymers
Equipment and Supplies

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Gyógyszerhatóanyag-kristályosodás valós idejucombining double acute accent vizsgálata és módosítása segédanyaggal. / Pataki, H.; Palésti, K.; Vajna, B.; Csontos, I.; Marosi, G.

In: Acta Pharmaceutica Hungarica, Vol. 81, No. 3, 2011, p. 109-124.

Research output: Contribution to journalArticle

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