Real-time monitoring of cellular dynamics using a microfluidic cell culture system with integrated electrode array and potentiostat

K. Zór, M. Vergani, A. Heiskanen, E. Landini, M. Carminati, V. Coman, I. Vedarethinam, P. Skafte-Pedersen, M. Skolimowski, A. Martinez Serrano, M. Kokaia, T. Ramos Moreno, A. Ghio, W. E. Svendsen, M. Dimaki, Zs Keresztes, M. Adamovski, U. Wollenberger, D. Sabourin, G. FerrariR. Raiteri, M. Sampietro, M. Dufva, J. Emnéus

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

A versatile microfluidic, multichamber cell culture and analysis system with an integrated electrode array and potentiostat suitable for electrochemical detection and microscopic imaging is presented in this paper. The system, which allows on-line electrode cleaning and modification, was developed for real-time monitoring of cellular dynamics, exemplified in this work by monitoring of redox metabolism inside living yeast cells and dopamine release from PC12 cells.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1532-1535
Number of pages4
Publication statusPublished - 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume3

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

Keywords

  • Cellular dynamics monitoring
  • Dopamine exocytosis
  • Microfluidic cell culture system
  • On-line measurement

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Zór, K., Vergani, M., Heiskanen, A., Landini, E., Carminati, M., Coman, V., Vedarethinam, I., Skafte-Pedersen, P., Skolimowski, M., Martinez Serrano, A., Kokaia, M., Ramos Moreno, T., Ghio, A., Svendsen, W. E., Dimaki, M., Keresztes, Z., Adamovski, M., Wollenberger, U., Sabourin, D., ... Emnéus, J. (2011). Real-time monitoring of cellular dynamics using a microfluidic cell culture system with integrated electrode array and potentiostat. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 1532-1535). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 3).