The reactivity of the pharmacologically active pyrido[1,2-a]pyrimidin-4-one ring system has been investigated, and its ring opening, catalytic hydrogenation, reduction by sodium borohydride. N-alkylation, and bromination are described. The hydrolysis, ammonolysis, and reaction with hydrazine of a 3-ethoxycarbonyl group are also discussed. The reactivity is compared with the charge distribution of the molecules calculated by quantum chemical methods.
|Number of pages||4|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - Dec 1 1974|
ASJC Scopus subject areas