Liver protecting drugs, silibinin, a flavonolignane, and the dehydroquinoline derivatives, CH 402 and MTDQ-DA, were shown to inhibit processes in which enzymaticaly or non-enzymatically generated free radicals were involved. Inorganic free radicals (N3,(SCN)2-, OH, Trp, CO2-, O2-) produced by pulse radiolysis readily react with the compounds, which transform into exceptionally long-lived, unreactive transients. Time evolution of the UV and visible spectra indicate that oxidising radicals form a phenoxyl type radical from silibinin, while OH forms an adduct by attacking, simultaneously, at various sites of the molecule. Superoxide radicals reduce silibinin and oxidise CH 402 and MTDQ-DA. It is concluded that the drugs might exhibit antioxidant behavior in living systems.
|Number of pages||3|
|Journal||Radiation Physics and Chemistry|
|Publication status||Published - Jan 1 1990|
|Event||Second International Meeting on Pulse Investigations in Physics, Chemistry and Biology - Czerniejewo, Pol|
Duration: Sep 12 1988 → Sep 17 1988
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