Reactions of inorganic free radicals with liver protecting drugs

I. Gyorgy, A. Blázovics, J. Fehér, G. Foldiak

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Liver protecting drugs, silibinin, a flavonolignane, and the dehydroquinoline derivatives, CH 402 and MTDQ-DA, were shown to inhibit processes in which enzymaticaly or non-enzymatically generated free radicals were involved. Inorganic free radicals (N3,(SCN)2-, OH, Trp, CO2-, O2-) produced by pulse radiolysis readily react with the compounds, which transform into exceptionally long-lived, unreactive transients. Time evolution of the UV and visible spectra indicate that oxidising radicals form a phenoxyl type radical from silibinin, while OH forms an adduct by attacking, simultaneously, at various sites of the molecule. Superoxide radicals reduce silibinin and oxidise CH 402 and MTDQ-DA. It is concluded that the drugs might exhibit antioxidant behavior in living systems.

Original languageEnglish
Pages (from-to)165-167
Number of pages3
JournalRadiation Physics and Chemistry
Volume36
Issue number2
Publication statusPublished - 1990

Fingerprint

liver
free radicals
drugs
methylidyne
inorganic peroxides
antioxidants
visible spectrum
radiolysis
adducts
pulses
molecules

ASJC Scopus subject areas

  • Radiation

Cite this

Reactions of inorganic free radicals with liver protecting drugs. / Gyorgy, I.; Blázovics, A.; Fehér, J.; Foldiak, G.

In: Radiation Physics and Chemistry, Vol. 36, No. 2, 1990, p. 165-167.

Research output: Contribution to journalArticle

@article{6dc7995f7b5b43399dc19cc7c74c1e87,
title = "Reactions of inorganic free radicals with liver protecting drugs",
abstract = "Liver protecting drugs, silibinin, a flavonolignane, and the dehydroquinoline derivatives, CH 402 and MTDQ-DA, were shown to inhibit processes in which enzymaticaly or non-enzymatically generated free radicals were involved. Inorganic free radicals (N3,(SCN)2-, OH, Trp, CO2-, O2-) produced by pulse radiolysis readily react with the compounds, which transform into exceptionally long-lived, unreactive transients. Time evolution of the UV and visible spectra indicate that oxidising radicals form a phenoxyl type radical from silibinin, while OH forms an adduct by attacking, simultaneously, at various sites of the molecule. Superoxide radicals reduce silibinin and oxidise CH 402 and MTDQ-DA. It is concluded that the drugs might exhibit antioxidant behavior in living systems.",
author = "I. Gyorgy and A. Bl{\'a}zovics and J. Feh{\'e}r and G. Foldiak",
year = "1990",
language = "English",
volume = "36",
pages = "165--167",
journal = "Radiation Physics and Chemistry",
issn = "0969-806X",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Reactions of inorganic free radicals with liver protecting drugs

AU - Gyorgy, I.

AU - Blázovics, A.

AU - Fehér, J.

AU - Foldiak, G.

PY - 1990

Y1 - 1990

N2 - Liver protecting drugs, silibinin, a flavonolignane, and the dehydroquinoline derivatives, CH 402 and MTDQ-DA, were shown to inhibit processes in which enzymaticaly or non-enzymatically generated free radicals were involved. Inorganic free radicals (N3,(SCN)2-, OH, Trp, CO2-, O2-) produced by pulse radiolysis readily react with the compounds, which transform into exceptionally long-lived, unreactive transients. Time evolution of the UV and visible spectra indicate that oxidising radicals form a phenoxyl type radical from silibinin, while OH forms an adduct by attacking, simultaneously, at various sites of the molecule. Superoxide radicals reduce silibinin and oxidise CH 402 and MTDQ-DA. It is concluded that the drugs might exhibit antioxidant behavior in living systems.

AB - Liver protecting drugs, silibinin, a flavonolignane, and the dehydroquinoline derivatives, CH 402 and MTDQ-DA, were shown to inhibit processes in which enzymaticaly or non-enzymatically generated free radicals were involved. Inorganic free radicals (N3,(SCN)2-, OH, Trp, CO2-, O2-) produced by pulse radiolysis readily react with the compounds, which transform into exceptionally long-lived, unreactive transients. Time evolution of the UV and visible spectra indicate that oxidising radicals form a phenoxyl type radical from silibinin, while OH forms an adduct by attacking, simultaneously, at various sites of the molecule. Superoxide radicals reduce silibinin and oxidise CH 402 and MTDQ-DA. It is concluded that the drugs might exhibit antioxidant behavior in living systems.

UR - http://www.scopus.com/inward/record.url?scp=0025342031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025342031&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0025342031

VL - 36

SP - 165

EP - 167

JO - Radiation Physics and Chemistry

JF - Radiation Physics and Chemistry

SN - 0969-806X

IS - 2

ER -