Reactions of inorganic free radicals with liver protecting drugs

I. Gyorgy, A. Blazovics, J. Feher, G. Foldiak

Research output: Contribution to journalConference article

4 Citations (Scopus)

Abstract

Liver protecting drugs, silibinin, a flavonolignane, and the dehydroquinoline derivatives, CH 402 and MTDQ-DA, were shown to inhibit processes in which enzymaticaly or non-enzymatically generated free radicals were involved. Inorganic free radicals (N3,(SCN)2-, OH, Trp, CO2-, O2-) produced by pulse radiolysis readily react with the compounds, which transform into exceptionally long-lived, unreactive transients. Time evolution of the UV and visible spectra indicate that oxidising radicals form a phenoxyl type radical from silibinin, while OH forms an adduct by attacking, simultaneously, at various sites of the molecule. Superoxide radicals reduce silibinin and oxidise CH 402 and MTDQ-DA. It is concluded that the drugs might exhibit antioxidant behavior in living systems.

Original languageEnglish
Pages (from-to)165-167
Number of pages3
JournalRadiation Physics and Chemistry
Volume36
Issue number2
Publication statusPublished - Jan 1 1990
EventSecond International Meeting on Pulse Investigations in Physics, Chemistry and Biology - Czerniejewo, Pol
Duration: Sep 12 1988Sep 17 1988

ASJC Scopus subject areas

  • Radiation

Fingerprint Dive into the research topics of 'Reactions of inorganic free radicals with liver protecting drugs'. Together they form a unique fingerprint.

  • Cite this