Re-establishing tolerance to DNA in humanized and murine models of SLE

Kalina Nikolova, Nikolina Mihaylova, Elisaveta Voynova, Nikola Kerekov, Vera Gesheva, J. Prechl, Maria Nikolova, Andrey Tchorbanov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

DNA-specific B cells in SLE represent a logical target for therapeutic intervention. We hypothesize that it is possible to re-establish tolerance to native DNA in SCID mice with cells transferred from SLE patients or from lupus-prone MRL/lpr mice by administering chimeric molecules, containing a monoclonal antibody against inhibitory B cell receptors coupled to a peptide that antigenically mimics DNA. These protein-engineered molecules are able to co-crosslink selectively the antigen receptors of B cells possessing anti-native DNA specificity with the inhibitory surface receptors, thus delivering a strong suppressive signal.

Original languageEnglish
Pages (from-to)499-502
Number of pages4
JournalAutoimmunity Reviews
Volume9
Issue number7
DOIs
Publication statusPublished - May 2010

Fingerprint

DNA
B-Lymphocytes
Inbred MRL lpr Mouse
B-Cell Antigen Receptors
SCID Mice
Monoclonal Antibodies
Peptides
Proteins
Therapeutics

Keywords

  • Chimeric molecules
  • Inhibitory B cell receptors
  • SCID models of SLE

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Nikolova, K., Mihaylova, N., Voynova, E., Kerekov, N., Gesheva, V., Prechl, J., ... Tchorbanov, A. (2010). Re-establishing tolerance to DNA in humanized and murine models of SLE. Autoimmunity Reviews, 9(7), 499-502. https://doi.org/10.1016/j.autrev.2010.02.009

Re-establishing tolerance to DNA in humanized and murine models of SLE. / Nikolova, Kalina; Mihaylova, Nikolina; Voynova, Elisaveta; Kerekov, Nikola; Gesheva, Vera; Prechl, J.; Nikolova, Maria; Tchorbanov, Andrey.

In: Autoimmunity Reviews, Vol. 9, No. 7, 05.2010, p. 499-502.

Research output: Contribution to journalArticle

Nikolova, K, Mihaylova, N, Voynova, E, Kerekov, N, Gesheva, V, Prechl, J, Nikolova, M & Tchorbanov, A 2010, 'Re-establishing tolerance to DNA in humanized and murine models of SLE', Autoimmunity Reviews, vol. 9, no. 7, pp. 499-502. https://doi.org/10.1016/j.autrev.2010.02.009
Nikolova, Kalina ; Mihaylova, Nikolina ; Voynova, Elisaveta ; Kerekov, Nikola ; Gesheva, Vera ; Prechl, J. ; Nikolova, Maria ; Tchorbanov, Andrey. / Re-establishing tolerance to DNA in humanized and murine models of SLE. In: Autoimmunity Reviews. 2010 ; Vol. 9, No. 7. pp. 499-502.
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