Re-establishing tolerance to DNA in humanized and murine models of SLE

Kalina Nikolova, Nikolina Mihaylova, Elisaveta Voynova, Nikola Kerekov, Vera Gesheva, Jozsef Prechl, Maria Nikolova, Andrey Tchorbanov

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

DNA-specific B cells in SLE represent a logical target for therapeutic intervention. We hypothesize that it is possible to re-establish tolerance to native DNA in SCID mice with cells transferred from SLE patients or from lupus-prone MRL/lpr mice by administering chimeric molecules, containing a monoclonal antibody against inhibitory B cell receptors coupled to a peptide that antigenically mimics DNA. These protein-engineered molecules are able to co-crosslink selectively the antigen receptors of B cells possessing anti-native DNA specificity with the inhibitory surface receptors, thus delivering a strong suppressive signal.

Original languageEnglish
Pages (from-to)499-502
Number of pages4
JournalAutoimmunity Reviews
Volume9
Issue number7
DOIs
Publication statusPublished - May 1 2010

Keywords

  • Chimeric molecules
  • Inhibitory B cell receptors
  • SCID models of SLE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Nikolova, K., Mihaylova, N., Voynova, E., Kerekov, N., Gesheva, V., Prechl, J., Nikolova, M., & Tchorbanov, A. (2010). Re-establishing tolerance to DNA in humanized and murine models of SLE. Autoimmunity Reviews, 9(7), 499-502. https://doi.org/10.1016/j.autrev.2010.02.009