Rational Synthesis of Dronic Acid Derivatives

György Keglevich, Alajos Grün, Sándor Garadnay, István Greiner

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6 Citations (Scopus)


The basic method for the synthesis of dronic acid derivatives (etidronate, fenidronate, pamidronate, alendronate, ibandronate, zoledronic acid, and risedronic acid) starting from the corresponding carboxylic acid, phosphorus trichloride and phosphorous acid is surveyed. The focus is on the optimized syntheses elaborated by us using only 3.2 equivalents of phosphorus trichloride as the P-reagent in methanesulfonic acid as the solvent.

Original languageEnglish
Pages (from-to)2116-2124
Number of pages9
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Issue number12
Publication statusPublished - Dec 2 2015



  • Dronic acids
  • dronates
  • hydroxy-methylenebisphosphonates
  • mechanism
  • synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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