Rational synthesis of α-hydroxyphosphonic derivatives including dronic acids

Alajos Grün, Zita Rádai, Dávid Illés Sőregi-Nagy, István Greiner, György Keglevich

Research output: Contribution to journalArticle


New, green methods have been elaborated for the syntheses of α-hydroxyphosphonates and α-hydroxymethylenebisphosphonic derivatives (HMBPs, dronates). α-Hydroxyphosphonates were prepared via the Pudovik reaction, while the synthesis of HMBPs has been performed in the three-component reaction of carboxylic acids, phosphorus trichloride and phosphorus acid.

Original languageEnglish
Pages (from-to)386-387
Number of pages2
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Issue number4-6
Publication statusPublished - May 27 2019


  • Pudovik reaction
  • green syntheses
  • ionic liquid
  • sulfolane
  • α-Hydroxymethylenebisphosphonates
  • α-hydroxyphosphonates

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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