Rate of preterm birth in pregnant women with vitamin e treatment: A population-based study

Liza Bártfai, Zoltán Bártfai, Iván Nedeczky, E. Puhó, F. Bánhidy, E. Czeizel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Vitamin E is frequently used for prevention/treatment of repeated or threatened abortion and threatened preterm delivery in Hungarian pregnant women, though, internationally this old-fashion method is not recommended. Methods: The rate of preterm birth of newborns in pregnant women with high dose (estimated daily dose 450mg) vitamin E treatment or without this treatment was compared in the population-based large data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities. Results: Of 38,151 newborns with any defect, 2,287 (6.0%) had mothers with vitamin E treatment. Pregnant women with vitamin E treatment had very high rate of threatened abortion (43.6% vs. 15.4%) and high rate of threatened preterm delivery (27.5% vs. 13.4%) compared to pregnant women without vitamin E treatment. Nevertheless, the gestational age at delivery was 0.2 week longer and rate of preterm births was lower in the newborns of pregnant women with vitamin E treatment (6.6% vs. 9.3%; adjusted OR with 95% CI: 0.71, 0.630.84). This preterm preventive effect of vitamin E treatment could not be explained by known confounders, though folic acid/multivitamins also reduced the rate of preterm birth. Conclusion: The study showed nearly 30% reduction in preterm births of pregnant women with vitamin E treatment.

Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume25
Issue number6
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Premature Birth
Vitamins
Vitamin E
Pregnant Women
Population
Threatened Abortion
Therapeutics
Newborn Infant
Folic Acid
Gestational Age
Mothers

Keywords

  • Population-based study
  • Pregnancy
  • Preterm birth
  • Vitamin E

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Rate of preterm birth in pregnant women with vitamin e treatment : A population-based study. / Bártfai, Liza; Bártfai, Zoltán; Nedeczky, Iván; Puhó, E.; Bánhidy, F.; Czeizel, E.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 25, No. 6, 06.2012, p. 575-580.

Research output: Contribution to journalArticle

@article{f140640526ce40468872c92a08d70be3,
title = "Rate of preterm birth in pregnant women with vitamin e treatment: A population-based study",
abstract = "Objective: Vitamin E is frequently used for prevention/treatment of repeated or threatened abortion and threatened preterm delivery in Hungarian pregnant women, though, internationally this old-fashion method is not recommended. Methods: The rate of preterm birth of newborns in pregnant women with high dose (estimated daily dose 450mg) vitamin E treatment or without this treatment was compared in the population-based large data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities. Results: Of 38,151 newborns with any defect, 2,287 (6.0{\%}) had mothers with vitamin E treatment. Pregnant women with vitamin E treatment had very high rate of threatened abortion (43.6{\%} vs. 15.4{\%}) and high rate of threatened preterm delivery (27.5{\%} vs. 13.4{\%}) compared to pregnant women without vitamin E treatment. Nevertheless, the gestational age at delivery was 0.2 week longer and rate of preterm births was lower in the newborns of pregnant women with vitamin E treatment (6.6{\%} vs. 9.3{\%}; adjusted OR with 95{\%} CI: 0.71, 0.630.84). This preterm preventive effect of vitamin E treatment could not be explained by known confounders, though folic acid/multivitamins also reduced the rate of preterm birth. Conclusion: The study showed nearly 30{\%} reduction in preterm births of pregnant women with vitamin E treatment.",
keywords = "Population-based study, Pregnancy, Preterm birth, Vitamin E",
author = "Liza B{\'a}rtfai and Zolt{\'a}n B{\'a}rtfai and Iv{\'a}n Nedeczky and E. Puh{\'o} and F. B{\'a}nhidy and E. Czeizel",
year = "2012",
month = "6",
doi = "10.3109/14767058.2011.587060",
language = "English",
volume = "25",
pages = "575--580",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Rate of preterm birth in pregnant women with vitamin e treatment

T2 - A population-based study

AU - Bártfai, Liza

AU - Bártfai, Zoltán

AU - Nedeczky, Iván

AU - Puhó, E.

AU - Bánhidy, F.

AU - Czeizel, E.

PY - 2012/6

Y1 - 2012/6

N2 - Objective: Vitamin E is frequently used for prevention/treatment of repeated or threatened abortion and threatened preterm delivery in Hungarian pregnant women, though, internationally this old-fashion method is not recommended. Methods: The rate of preterm birth of newborns in pregnant women with high dose (estimated daily dose 450mg) vitamin E treatment or without this treatment was compared in the population-based large data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities. Results: Of 38,151 newborns with any defect, 2,287 (6.0%) had mothers with vitamin E treatment. Pregnant women with vitamin E treatment had very high rate of threatened abortion (43.6% vs. 15.4%) and high rate of threatened preterm delivery (27.5% vs. 13.4%) compared to pregnant women without vitamin E treatment. Nevertheless, the gestational age at delivery was 0.2 week longer and rate of preterm births was lower in the newborns of pregnant women with vitamin E treatment (6.6% vs. 9.3%; adjusted OR with 95% CI: 0.71, 0.630.84). This preterm preventive effect of vitamin E treatment could not be explained by known confounders, though folic acid/multivitamins also reduced the rate of preterm birth. Conclusion: The study showed nearly 30% reduction in preterm births of pregnant women with vitamin E treatment.

AB - Objective: Vitamin E is frequently used for prevention/treatment of repeated or threatened abortion and threatened preterm delivery in Hungarian pregnant women, though, internationally this old-fashion method is not recommended. Methods: The rate of preterm birth of newborns in pregnant women with high dose (estimated daily dose 450mg) vitamin E treatment or without this treatment was compared in the population-based large data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities. Results: Of 38,151 newborns with any defect, 2,287 (6.0%) had mothers with vitamin E treatment. Pregnant women with vitamin E treatment had very high rate of threatened abortion (43.6% vs. 15.4%) and high rate of threatened preterm delivery (27.5% vs. 13.4%) compared to pregnant women without vitamin E treatment. Nevertheless, the gestational age at delivery was 0.2 week longer and rate of preterm births was lower in the newborns of pregnant women with vitamin E treatment (6.6% vs. 9.3%; adjusted OR with 95% CI: 0.71, 0.630.84). This preterm preventive effect of vitamin E treatment could not be explained by known confounders, though folic acid/multivitamins also reduced the rate of preterm birth. Conclusion: The study showed nearly 30% reduction in preterm births of pregnant women with vitamin E treatment.

KW - Population-based study

KW - Pregnancy

KW - Preterm birth

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=84861065544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861065544&partnerID=8YFLogxK

U2 - 10.3109/14767058.2011.587060

DO - 10.3109/14767058.2011.587060

M3 - Article

C2 - 22443476

AN - SCOPUS:84861065544

VL - 25

SP - 575

EP - 580

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 6

ER -