Rare case of hereditary angioedema and concomitant Crohn's disease

H. Farkas, L. Gyeney, E. Nemesanszky, G. Kaldi, F. Kukan, I. Masszi, J. Soos, M. Bely, E. Farkas, G. Fust, L. Varga

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1 Citation (Scopus)


The authors present a case of Crohn's disease coinciding with characteristic clinical and laboratory signs of a hereditary disorder, the C1-esterase inhibitor deficiency. Heterozygous deficiency of this protein - an inhibitor of several plasma enzyme systems - is manifested by a well- characterized disease called the hereditary angioedema (HAE). Although the coincidence of these two diseases had been described previously, no detailed analysis of such a case had been reported until now. Described here, is a case of a 37 years old male (17 year old disease history) with characteristic abdominal manifestations of C1 esterase inhibitor deficiency which alternated with exacerbations of Crohn's disease. Differential diagnostic pitfalls have been discussed along with available and efficacious therapeutic methods.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalMedical Science Monitor
Issue number2
Publication statusPublished - Jan 1 1998



  • Acute abdominal edematous attack
  • C1 INH concentrate
  • C1 esterase inhibitor (C1 INH) deficiency
  • Crohn's disease
  • Danazol
  • Hereditary angioedema (HAE)
  • Long term prophylaxis
  • Transitory ascites

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Farkas, H., Gyeney, L., Nemesanszky, E., Kaldi, G., Kukan, F., Masszi, I., Soos, J., Bely, M., Farkas, E., Fust, G., & Varga, L. (1998). Rare case of hereditary angioedema and concomitant Crohn's disease. Medical Science Monitor, 4(2), 349-354.