Rare angioproliferative tumors mimicking aggressive spinal hemangioma with epidural expansion

Zsolt Kulcsár, Róbert Veres, Zoltán Hanzély, Zsolt Berentei, Miklós Marosfoi, István Nyáry, István Szikora

Research output: Contribution to journalArticle

3 Citations (Scopus)


Background and purpose - We present two cases of angio-proliferative tumors that were misdiagnosed and treated as typical hemangiomas with epidural expansion. Materials and methods - Two middle-aged women presented with symptoms and radiological signs characteristic for aggressive hemangioma with epidural expansion. In the first case preoperative embolization and decompressive surgery with open transpedicular vertebroplasty was performed. Within less than a year, epidural recurrence of the tumor prompted for radical excision and corpectomy. The diagnosis after the histological studies and the further clinical evolution was metastasizing leiomyomatosis. No further recurrence occured during the next 6 years. In the second case percutaneous vertebroplasty was performed and complicated by epidural polymethyl-methacrylcate (PMMA) leakage, requiring urgent decompressive surgery. Histological study of the lesion raised the possibility of myopericytoma. This was confirmed 16 months later when complete vertebrectomy was performed due to severe epidural propagation of the recurring tumor. No further recurrence occurred in next the two years. Conclusions - Rare angio-proliferative tumors, like benign metastasizing leiomyoma and myopericytoma radiologically may resemble aggressive vertebral hemangiomas of the spine. Unlike hemangiomas, such tumors require radical removal due to their likely recurrence. As imaging studies may not be able to completely exclude such pathologies, bone biopsy and thorough histopathological studies are warranted prior to the therapeutic decision.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalIdeggyogyaszati szemle
Issue number1-2
Publication statusPublished - Jan 30 2012


  • Aggressive spinal hemangioma
  • Embolization
  • Metastasizing leiomyoma
  • Myopericytoma
  • Sclerotization
  • Vertebroplasty

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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