RARβ2 suppression in head and neck squamous cell carcinoma correlates with site, histology and age

Judit Olasz, Alíz Juhász, E. Remenár, Helga Engi, M. Bak, O. Csuka, M. Kásler

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Retinoids as important growth and differentiation regulating agents have a potential role in the chemoprevention of head and neck squamous cell carcinoma (HNSCC). Despite the promising preclinical and early clinical findings, limitations of application are raised by intrinsic resistance acquired during carcinogenesis. Retinoic acid receptor β2 (RARβ2) is one of the proximate mediators of retinoid signalling and its expression is often diminished in early stages of head and neck carcinogenesis. One form of retinoid resistance has been associated with the methylation-induced silencing of the RARβ gene. We studied primary HNSCC samples of different anatomical sites in respect of methylation, expression and allelic loss of RARβ gene. A strong correlation (p

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalOncology Reports
Volume18
Issue number1
Publication statusPublished - Jul 2007

Fingerprint

Retinoic Acid Receptors
Retinoids
Histology
Methylation
Carcinogenesis
Loss of Heterozygosity
Chemoprevention
Gene Silencing
Neck
Head
Growth
Genes
Carcinoma, squamous cell of head and neck

Keywords

  • Chemoprevention
  • HNSCC
  • Promoter hypermethylation
  • RARβ2 expression
  • Retinoic acid
  • Retinoid resistance
  • Squamous differentiation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

RARβ2 suppression in head and neck squamous cell carcinoma correlates with site, histology and age. / Olasz, Judit; Juhász, Alíz; Remenár, E.; Engi, Helga; Bak, M.; Csuka, O.; Kásler, M.

In: Oncology Reports, Vol. 18, No. 1, 07.2007, p. 105-112.

Research output: Contribution to journalArticle

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AU - Csuka, O.

AU - Kásler, M.

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