Rapid test for fecal calprotectin levels in children with Crohn disease

K. L. Kolho, D. Turner, G. Veereman-Wauters, M. Sladek, L. De Ridder, R. Shaoul, A. Paerregaard, J. Amil Dias, S. Koletzko, F. Nuti, Y. Bujanover, A. Staiano, K. Bochenek, L. Finnby, A. Levine, G. Verès

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Assessment of fecal calprotectin, a surrogate marker of mucosal inflammation, is a promising means to monitor therapeutic response in pediatric inflammatory bowel disease, especially if the result is readily available. We tested the performance of a novel calprotectin rapid test, Quantum Blue, versus the conventional enzyme-linked immunosorbent assay in 134 stool samples from 56 pediatric patients with Crohn disease. The intraclass correlation coefficient analysis reflected good agreement (intraclass correlation coefficient 0.97 [95% confidence interval 0.95-0.98]) but agreement was better in lower values, where dilutions were not required. Using a cutoff of 100μg/g for normal values, the percentage agreement between the 2 tests was 87%. The optimal cutoff values to guide clinical decisions in the therapy of inflammatory bowel disease have yet to be determined.

Original languageEnglish
Pages (from-to)436-439
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume55
Issue number4
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Leukocyte L1 Antigen Complex
Inflammatory Bowel Diseases
Crohn Disease
Pediatrics
Reference Values
Biomarkers
Enzyme-Linked Immunosorbent Assay
Confidence Intervals
Inflammation
Therapeutics

Keywords

  • Fecal biomarkers
  • Inflammatory bowel disease
  • Pediatric

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Rapid test for fecal calprotectin levels in children with Crohn disease. / Kolho, K. L.; Turner, D.; Veereman-Wauters, G.; Sladek, M.; De Ridder, L.; Shaoul, R.; Paerregaard, A.; Dias, J. Amil; Koletzko, S.; Nuti, F.; Bujanover, Y.; Staiano, A.; Bochenek, K.; Finnby, L.; Levine, A.; Verès, G.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 55, No. 4, 10.2012, p. 436-439.

Research output: Contribution to journalArticle

Kolho, KL, Turner, D, Veereman-Wauters, G, Sladek, M, De Ridder, L, Shaoul, R, Paerregaard, A, Dias, JA, Koletzko, S, Nuti, F, Bujanover, Y, Staiano, A, Bochenek, K, Finnby, L, Levine, A & Verès, G 2012, 'Rapid test for fecal calprotectin levels in children with Crohn disease', Journal of Pediatric Gastroenterology and Nutrition, vol. 55, no. 4, pp. 436-439. https://doi.org/10.1097/MPG.0b013e318253cff1
Kolho, K. L. ; Turner, D. ; Veereman-Wauters, G. ; Sladek, M. ; De Ridder, L. ; Shaoul, R. ; Paerregaard, A. ; Dias, J. Amil ; Koletzko, S. ; Nuti, F. ; Bujanover, Y. ; Staiano, A. ; Bochenek, K. ; Finnby, L. ; Levine, A. ; Verès, G. / Rapid test for fecal calprotectin levels in children with Crohn disease. In: Journal of Pediatric Gastroenterology and Nutrition. 2012 ; Vol. 55, No. 4. pp. 436-439.
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